[HTML][HTML] Inhibition of epithelial–mesenchymal transition in retinal pigment epithelial cells by a retinoic acid receptor-α agonist

Y Kobayashi, K Tokuda, C Yamashiro, F Higashijima… - Scientific Reports, 2021 - nature.com
Epithelial–mesenchymal transition (EMT) in retinal pigment epithelial (RPE) cells plays a
key role in proliferative retinal diseases such as age-related macular degeneration by …

Role of CRP2-MRTF interaction in functions of myofibroblasts

…, Y Kobayashi, C Yamashiro, F Higashijima… - Cell Structure and …, 2023 - jstage.jst.go.jp
Inflammatory response induces phenotypic modulation of fibroblasts into myofibroblasts.
Although transforming growth factor-βs (TGF-βs) evoke such transition, the details of the …

[HTML][HTML] Combination of blockade of endothelin signalling and compensation of IGF1 expression protects the retina from degeneration

…, M Shirai, M Toriyama, F Higashijima… - Cellular and Molecular …, 2024 - Springer
Retinitis pigmentosa (RP) and macular dystrophy (MD) cause severe retinal dysfunction,
affecting 1 in 4000 people worldwide. This disease is currently assumed to be intractable, …

[HTML][HTML] Influence of extended depth of focus intraocular lenses on visual field sensitivity

…, T Yoshimoto, Y Kobayashi, F Higashijima… - PLoS …, 2020 - journals.plos.org
Purpose To investigate the influence of EDOF IOLs, TECNIS Symfony ® (Johnson & Johnson
Surgical Vision, Inc.), on visual field sensitivity and to compare the IOLs with other kinds of …

[HTML][HTML] Evaluation of microaneurysms as predictors of therapeutic response to anti-VEGF therapy in patients with DME

M Hatano, F Higashijima, T Yoshimoto, T Ogata… - Plos one, 2022 - journals.plos.org
Administration of intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is
the first-line therapy for diabetic macular oedema (DME). However, some patients show no or …

Early manifestations and differential gene expression associated with photoreceptor degeneration in Prom1-deficient retina

…, C Yamashiro, T Ogata, F Higashijima… - Disease models & …, 2021 - journals.biologists.com
Retinitis pigmentosa (RP) and macular dystrophy (MD) are characterized by gradual
photoreceptor death in the retina and are often associated with genetic mutations, including those …

[HTML][HTML] SARS-CoV-2 infection status in corneal preservation solution and COVID-19 prevalence after corneal transplantation

…, M Mikuni, R Nakamura, A Sakuma, F Higashijima… - Scientific Reports, 2024 - nature.com
The potential risks associated with organs from COVID-19-infected donors were unclear. To
determine the SARS-CoV-2 infection status of corneas transplanted during the COVID-19 …

Prominin‐1 deletion results in spermatogenic impairment, sperm morphological defects, and infertility in mice

…, Y Kobayashi, S Oka, F Higashijima… - Reproductive …, 2023 - Wiley Online Library
Purpose Spermatogenesis is a complex process orchestrated by several essential genes.
Prominin‐1 (Prom1/PROM1) is a gene that is expressed in the testis but with a poorly …

[HTML][HTML] Benzalkonium chloride-induced myofibroblastic transdifferentiation of Tenon's capsule fibroblasts is inhibited by coculture with corneal epithelial cells or by …

C Yamashiro, K Tokuda, Y Kobayashi, F Higashijima… - Scientific Reports, 2021 - nature.com
Benzalkonium chloride (BAC) is used as a preservative in eyedrops but induces subconjunctival
fibrosis that can result in failure of glaucoma surgery. Tenon’s capsule fibroblasts in …

[HTML][HTML] Molecular mechanisms of TGFβ-mediated EMT of retinal pigment epithelium in subretinal fibrosis of age-related macular degeneration

F Higashijima, M Hasegawa, T Yoshimoto… - Frontiers in …, 2023 - frontiersin.org
Age-related macular degeneration (AMD) is one of the leading causes of blindness in the
elderly, affecting the macula of the retina and resulting in vision loss. There are two types of …