Mouse embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are in a
high-flux metabolic state, with a high dependence on threonine catabolism. However, little is …

Methionine restriction extends the lifespan of various model organisms. Limiting S-adenosyl-methionine
(SAM) synthesis, the first metabolic reaction of dietary methionine, extends …

The enteroendocrine cell (EEC)-derived incretins play a pivotal role in regulating the secretion
of glucagon and insulins in mammals. Although glucagon-like and insulin-like hormones …

Environmental stresses experienced during development exert many long-term effects upon
health and disease. For example, chemical oxidants or genetic perturbations that induce …

Sterile inflammation triggered by endogenous factors is thought to contribute to the
pathogenesis of acute and chronic inflammatory diseases. Here, we demonstrate that apoptosis-…

The intake of dietary protein regulates growth, metabolism, fecundity and lifespan across
various species, which makes amino acid (AA)-sensing vital for adaptation to the nutritional …

The LacZ gene, which encodes Escherichia coli β‐galactosidase, is widely used as a marker
for cells with targeted gene expression or disruption. However, it has been difficult to detect …

Detecting multiple enzyme activities simultaneously with high spatial specificity is a promising
strategy to investigate complex biological phenomena, and Raman imaging would be an …

We have developed an activatable photosensitizer capable of specifically inducing the death
of β‐galactosidase‐expressing cells in response to photoirradiation. By using a selenium‐…

The intestine has direct contact with nutritional information. The mechanisms by which particular
dietary molecules affect intestinal homeostasis are not fully understood. In this study, we …