Abstract Development of intracellular delivery methods for antisense DNA and siRNA is
important. Previously reported methods using liposomes or receptor‐ligands take several hours …

Messenger RNAs (mRNAs) with phosphorothioate modification (PS‐mRNA) to the phosphate
site of A, G, C, and U with all 16 possible combinations were prepared, and the translation …

We herein report the first covalent G-site-binding inhibitor for GST, GS-ESF (1), which
irreversibly inhibited the GSTP1-1 function. LC-MS/MS and X-ray structure analyses of the …

Glutathione S‐transferase π (GSTP 1‐1 ) is overexpressed in many types of cancer and is
involved in drug resistance. Therefore, GSTP 1‐1 is an important target in cancer therapy, and …

We herein report a new approach for RNA interference, so-called “build-up RNAi” approach,
where single-strand circular RNAs with a photocleavable unit or disulfide moiety were used …

Circular RNA without a stop codon enables rolling circle translation. To produce circular
RNAs, we carried out one-pot chemical synthesis of circular RNA from RNA fragments with the …

Sequence-specific detection of intracellular RNA is one of the most important approaches to
understand life phenomena. However, it is difficult to detect RNA in living cells because of …

siRNA is a powerful method to suppress specific gene expression and has recently been
utilized for molecular biology as well as medicine. However, introduction of dsRNA stimulates …

The salvage pathways of nucleotide biosynthesis are more diverse and are less well
understood as compared with de novo pathways. Uridine-cytidine kinase (UCK) is the rate-limiting …

Optical observation of a planar lipid bilayer is an effective method of lipid bilayer
characterization. However, previous methods for optically observable lipid bilayer formation are …