[HTML][HTML] 40 years of IGF1: IGF1 receptor signaling pathways
F Hakuno, SI Takahashi - Journal of molecular endocrinology, 2018 - jme.bioscientifica.com
Insulin-like growth factors (IGFs) bind specifically to the IGF1 receptor on the cell surface of
targeted tissues. Ligand binding to the α subunit of the receptor leads to a conformational …
targeted tissues. Ligand binding to the α subunit of the receptor leads to a conformational …
[HTML][HTML] Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity
…, H Yoshihara, H Furuta, H Kamei, F Hakuno… - Nature …, 2015 - nature.com
Insulin-like growth factors (IGFs) induce proliferation of various cell types and play important
roles in somatic growth and cancer development. Phosphorylation of insulin receptor …
roles in somatic growth and cancer development. Phosphorylation of insulin receptor …
[PDF][PDF] KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells
…, K Sasaki, Y Horikoshi, A Suzuki, T Ohtsuka, F Hakuno… - Current biology, 2011 - cell.com
Epithelial cells possess apical-basolateral polarity and form tight junctions (TJs) at the apical-lateral
border, separating apical and basolateral membrane domains. The PAR3-aPKC-…
border, separating apical and basolateral membrane domains. The PAR3-aPKC-…
[PDF][PDF] Serine phosphorylation by mTORC1 promotes IRS-1 degradation through SCFβ-TRCP E3 ubiquitin ligase
The insulin receptor substrate IRS-1 is a key substrate of insulin and insulin-like growth factor
(IGF) receptor tyrosine kinases that mediates their metabolic and growth-promoting actions…
(IGF) receptor tyrosine kinases that mediates their metabolic and growth-promoting actions…
[HTML][HTML] The inner nuclear membrane protein Nemp1 is a new type of RanGTP-binding protein in eukaryotes
T Shibano, H Mamada, F Hakuno, SI Takahashi… - Plos one, 2015 - journals.plos.org
The inner nuclear membrane (INM) protein Nemp1/TMEM194A has previously been
suggested to be involved in eye development in Xenopus, and contains two evolutionarily …
suggested to be involved in eye development in Xenopus, and contains two evolutionarily …
RNautophagy/DNautophagy possesses selectivity for RNA/DNA substrates
…, Y Fujiwara, H Kikuchi, S Aizawa, F Hakuno… - Nucleic acids …, 2015 - academic.oup.com
Lysosomes can degrade various biological macromolecules, including nucleic acids,
proteins and lipids. Recently, we identified novel nucleic acid-degradation systems termed …
proteins and lipids. Recently, we identified novel nucleic acid-degradation systems termed …
IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling
…, S Yokoyama, K Chida, J Weghuber, F Hakuno… - Elife, 2018 - elifesciences.org
10.7554/eLife.32893.001 Insulin-like growth factor-I receptor (IGF-IR) preferentially
regulates the long-term IGF activities including growth and metabolism. Kinetics of ligand-dependent …
regulates the long-term IGF activities including growth and metabolism. Kinetics of ligand-dependent …
Cytosolic domain of SIDT2 carries an arginine-rich motif that binds to RNA/DNA and is important for the direct transport of nucleic acids into lysosomes
RNautophagy and DNautophagy (RDA) are unconventional autophagic pathways where
nucleic acids are directly transported through the lysosomal membrane, then degraded inside …
nucleic acids are directly transported through the lysosomal membrane, then degraded inside …
[HTML][HTML] The novel functions of high-molecular-mass complexes containing insulin receptor substrates in mediation and modulation of insulin-like activities: emerging …
F Hakuno, T Fukushima, Y Yoneyama… - Frontiers in …, 2015 - frontiersin.org
Insulin-like peptides, such as insulin-like growth factors (IGFs) and insulin, induce a variety
of bioactivities, such as growth, differentiation, survival, increased anabolism, and decreased …
of bioactivities, such as growth, differentiation, survival, increased anabolism, and decreased …
Signalling pathways of insulin-like growth factor-I that are augmented by cAMP in FRTL-5 cells
…, H SAKAMOTO, Y ITO, F HAKUNO… - Biochemical …, 2000 - portlandpress.com
We have reported that pretreatment of rat FRTL-5 thyroid cells with thyrotropin (TSH) markedly
potentiates the mitogenic response to insulin-like growth factor-I (IGF-I). The present study …
potentiates the mitogenic response to insulin-like growth factor-I (IGF-I). The present study …