Recent progress in the analysis of transcriptional regulation has revealed the presence of
an exquisite functional network comprising the Maf and Cap ’n’ collar (CNC) families of …

Cells are equipped with a number of transcriptional factors that safeguard against various
environmental insults. Proteasomal protein degradation plays an important role in the Keap1-…

The small Maf proteins (sMafs) are basic region leucine zipper (bZIP)-type transcription factors.
The basic region of the Maf family is unique among the bZIP factors, and it contributes to …

The Tohoku Medical Megabank Organization reports the whole-genome sequences of 1,070
healthy Japanese individuals and construction of a Japanese population reference panel (…

NF-E2-related factor 2 (Nrf2) is a key transcription factor that is critical for cellular defense
against oxidative and xenobiotic insults. Nrf2 heterodimerizes with small Maf (sMaf) proteins …

The small Maf proteins, MafF, MafG, and MafK, possess a leucine zipper (Zip) domain that is
required for homodimer or heterodimer complex formation with other bZip transcription …

Nrf1 is a member of the vertebrate Cap'n'Collar (CNC) transcription factor family that commonly
contains a unique basic-leucine zipper domain. Among CNC family members, Nrf2 is …

While small Maf proteins have been suggested to be essential for the Nrf2-mediated activation
of antioxidant response element (ARE)-dependent genes, the extent of their requirement …

Synthetic triterpenoids have been developed, which are potent inducers of cytoprotective
enzymes and inhibitors of inflammation, greatly improving on the weak activity of naturally …

Metabolic reprogramming occurs in response to the cellular environment to mediate
differentiation 1 , 2 , 3 , but the fundamental mechanisms linking metabolic processes to …