Targeted genome editing via engineered nucleases is an exciting area of biomedical research
and holds potential for clinical applications. Despite rapid advances in the field, in vivo …

Radial glia cells function as neural stem cells in the developing brain and generate self-renewing
and differentiating daughter cells by asymmetric cell divisions. During these divisions, …

The mechanisms governing the expansion of neuron number in specific brain regions are
still poorly understood. Enlarged neuron numbers in different species are often anticipated by …

During mammalian development, neuroepithelial cells function as mitotic progenitors, which
self-renew and generate neurons. Although spindle orientation is important for such …

The lymphatic vasculature is a blind-ended network crucial for tissue-fluid homeostasis,
immune surveillance and lipid absorption from the gut. Recent evidence has proposed an …

Two high molecular weight heat shock proteins, HSP90 (Mr, 90,000) and HSP100 (Mr,
100,000), were separately purified from extracts of cultured cells of a mouse lymphoma cell line, …

Asymmetric cell division is a general process used in many developmental contexts to
create two differently fated cells from a single progenitor cell. Intrinsic mechanisms like the …

Cellular diversity during development arises in part from asymmetric divisions, which generate
two distinct cells by transmitting localized determinants from a progenitor cell into one …

ASYMMETRIC divisions that produce two distinct cells play fundamental roles in generating
different cell types during development 1,2 . In the Drosophilacentral nervous system, neural …

The orientation of the mitotic spindle relative to the cell axis determines whether polarized
cells undergo symmetric or asymmetric divisions. Drosophila epithelial cells and neuroblasts …