User profiles for Fusun Doldur-Balli
Fusun Doldur BalliUniversity of Pennsylvania Verified email at pennmedicine.upenn.edu Cited by 47 |
Synaptic dysfunction connects autism spectrum disorder and sleep disturbances: A perspective from studies in model organisms
Sleep disturbances (SD) accompany many neurodevelopmental disorders, suggesting SD is
a transdiagnostic process that can account for behavioral deficits and influence underlying …
a transdiagnostic process that can account for behavioral deficits and influence underlying …
Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep
Genome-wide association studies (GWAS) in humans have identified loci robustly associated
with several heritable diseases or traits, yet little is known about the functional roles of the …
with several heritable diseases or traits, yet little is known about the functional roles of the …
[HTML][HTML] Pleiotropic effects of a high confidence Autism Spectrum Disorder gene, arid1b, on zebrafish sleep
Sleep fulfills critical functions in neurodevelopment, such as promoting synaptic plasticity,
neuronal wiring, and brain connectivity which are critical phenomena in Autism Spectrum …
neuronal wiring, and brain connectivity which are critical phenomena in Autism Spectrum …
[HTML][HTML] Screening effects of HCN channel blockers on sleep/wake behavior in zebrafish
F Doldur-Balli, SP Smieszek, BT Keenan… - Frontiers in …, 2024 - frontiersin.org
Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels generate electrical
rhythmicity in various tissues although primarily heart, retina and brain. The HCN channel …
rhythmicity in various tissues although primarily heart, retina and brain. The HCN channel …
[HTML][HTML] Characterization of a novel zebrafish (Danio rerio) gene, wdr81, associated with cerebellar ataxia, mental retardation and dysequilibrium syndrome (CAMRQ …
Background WDR81 (WD repeat-containing protein 81) is associated with cerebellar ataxia,
mental retardation and disequilibrium syndrome (CAMRQ2, [MIM 610185]). Human and …
mental retardation and disequilibrium syndrome (CAMRQ2, [MIM 610185]). Human and …
Variant-to-gene-mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as novel regulator of sleep
Sleep is nearly ubiquitous throughout the animal kingdom, with deficiencies in sleep having
been linked to a wide range of human disorders and diseases. While genome wide …
been linked to a wide range of human disorders and diseases. While genome wide …
[HTML][HTML] Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q
Although genome wide association studies (GWAS) have been crucial for the identification
of loci associated with sleep traits and disorders, the method itself does not directly uncover …
of loci associated with sleep traits and disorders, the method itself does not directly uncover …
Mammalian target of rapamycin (mTOR), aging, neuroscience, and their association with aging-related diseases
Normal aging is accompanied by cognitive impairment with subtle cellular and molecular
changes in the brain, whereas, pathological brain aging manifests as severe behavioral …
changes in the brain, whereas, pathological brain aging manifests as severe behavioral …
Zebrafish screen of high-confidence targets at insomnia GWAS loci implicates MEIS1, SKIV2L, and ARFGAP2 as conserved regulators of sleep-wake behaviors
Study objectives Insomnia is a pervasive sleep disorder with heritability estimates ranging
from 22-59 percent. Human genome-wide association studies (GWAS) have identified more …
from 22-59 percent. Human genome-wide association studies (GWAS) have identified more …
Developing a pipeline for translating genome-wide association signals to behavioral correlates of sleep dysfunction.
…, C Lasconi, E Brown, J Pippin, A Wells, F Doldur-Balli… - 2022 - cabidigitallibrary.org
Introduction: Insomnia is a pervasive sleep disorder affecting up to one-third of the adult US
population. An extensive amount of genetic association data from genome wide association …
population. An extensive amount of genetic association data from genome wide association …