User profiles for Fusun Doldur-Balli

Fusun Doldur Balli

University of Pennsylvania
Verified email at pennmedicine.upenn.edu
Cited by 47

Synaptic dysfunction connects autism spectrum disorder and sleep disturbances: A perspective from studies in model organisms

F Doldur-Balli, T Imamura, OJ Veatch, NN Gong… - Sleep medicine …, 2022 - Elsevier
Sleep disturbances (SD) accompany many neurodevelopmental disorders, suggesting SD is
a transdiagnostic process that can account for behavioral deficits and influence underlying …

Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep

…, EB Brown, JA Pippin, AD Wells, F Doldur-Balli… - Science …, 2023 - science.org
Genome-wide association studies (GWAS) in humans have identified loci robustly associated
with several heritable diseases or traits, yet little is known about the functional roles of the …

[HTML][HTML] Pleiotropic effects of a high confidence Autism Spectrum Disorder gene, arid1b, on zebrafish sleep

F Doldur-Balli, AJ Zimmerman, BT Keenan… - Neurobiology of Sleep …, 2023 - Elsevier
Sleep fulfills critical functions in neurodevelopment, such as promoting synaptic plasticity,
neuronal wiring, and brain connectivity which are critical phenomena in Autism Spectrum …

[HTML][HTML] Screening effects of HCN channel blockers on sleep/wake behavior in zebrafish

F Doldur-Balli, SP Smieszek, BT Keenan… - Frontiers in …, 2024 - frontiersin.org
Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels generate electrical
rhythmicity in various tissues although primarily heart, retina and brain. The HCN channel …

[HTML][HTML] Characterization of a novel zebrafish (Danio rerio) gene, wdr81, associated with cerebellar ataxia, mental retardation and dysequilibrium syndrome (CAMRQ …

F Doldur-Balli, MN Ozel, S Gulsuner, AB Tekinay… - BMC neuroscience, 2015 - Springer
Background WDR81 (WD repeat-containing protein 81) is associated with cerebellar ataxia,
mental retardation and disequilibrium syndrome (CAMRQ2, [MIM 610185]). Human and …

Variant-to-gene-mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as novel regulator of sleep

…, EB Brown, JA Pippin, AD Wells, F Doldur-Balli… - bioRxiv, 2021 - biorxiv.org
Sleep is nearly ubiquitous throughout the animal kingdom, with deficiencies in sleep having
been linked to a wide range of human disorders and diseases. While genome wide …

[HTML][HTML] Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q

…, EB Brown, JA Pippin, AD Wells, F Doldur-Balli… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Although genome wide association studies (GWAS) have been crucial for the identification
of loci associated with sleep traits and disorders, the method itself does not directly uncover …

Mammalian target of rapamycin (mTOR), aging, neuroscience, and their association with aging-related diseases

ED Celebi-Birand, ET Karoglu, F Doldur-Balli… - Molecules to Medicine …, 2016 - Elsevier
Normal aging is accompanied by cognitive impairment with subtle cellular and molecular
changes in the brain, whereas, pathological brain aging manifests as severe behavioral …

Zebrafish screen of high-confidence targets at insomnia GWAS loci implicates MEIS1, SKIV2L, and ARFGAP2 as conserved regulators of sleep-wake behaviors

AJ Zimmerman, F Doldur-Balli, BT Keenan, ZY Shetty… - bioRxiv, 2022 - biorxiv.org
Study objectives Insomnia is a pervasive sleep disorder with heritability estimates ranging
from 22-59 percent. Human genome-wide association studies (GWAS) have identified more …

Developing a pipeline for translating genome-wide association signals to behavioral correlates of sleep dysfunction.

…, C Lasconi, E Brown, J Pippin, A Wells, F Doldur-Balli… - 2022 - cabidigitallibrary.org
Introduction: Insomnia is a pervasive sleep disorder affecting up to one-third of the adult US
population. An extensive amount of genetic association data from genome wide association …