User profiles for Fuzhong Zhang

Fuzhong Zhang

Professor, Washington University in St. Louis
Verified email at seas.wustl.edu
Cited by 7983

Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids

F Zhang, JM Carothers, JD Keasling - Nature biotechnology, 2012 - nature.com
Microbial production of chemicals is now an attractive alternative to chemical synthesis. Current
efforts focus mainly on constructing pathways to produce different types of molecules 1 , …

Recombinant spidroins fully replicate primary mechanical properties of natural spider silk

…, W Huang, DL Kaplan, JM Galazka, F Zhang - …, 2018 - ACS Publications
Despite significant efforts to engineer their heterologous production, recombinant spider silk
proteins (spidroins) have yet to replicate the unparalleled combination of high strength and …

A biosynthetic hybrid spidroin-amyloid-mussel foot protein for underwater adhesion on diverse surfaces

…, ED Hoppe, YS Jun, GM Genin, F Zhang - … applied materials & …, 2021 - ACS Publications
Strong underwater adhesives are attractive materials for biomedical healing and underwater
repair, but their success in applications has been limited, owing to challenges with …

Negative feedback regulation of fatty acid production based on a malonyl-CoA sensor–actuator

D Liu, Y Xiao, BS Evans, F Zhang - ACS synthetic biology, 2015 - ACS Publications
Engineering metabolic biosynthetic pathways has enabled the microbial production of many
useful chemicals. However, pathway productivities and yields are often limited by metabolic …

Microbial engineering for the production of advanced biofuels

PP Peralta-Yahya, F Zhang, SB Del Cardayre… - Nature, 2012 - nature.com
Advanced biofuels produced by microorganisms have similar properties to petroleum-based
fuels, and can 'drop in' to the existing transportation infrastructure. However, producing …

Engineering dynamic pathway regulation using stress-response promoters

RH Dahl, F Zhang, J Alonso-Gutierrez, E Baidoo… - Nature …, 2013 - nature.com
Heterologous pathways used in metabolic engineering may produce intermediates toxic to
the cell. Dynamic control of pathway enzymes could prevent the accumulation of these …

[HTML][HTML] BglBrick vectors and datasheets: a synthetic biology platform for gene expression

TS Lee, RA Krupa, F Zhang, M Hajimorad… - Journal of biological …, 2011 - Springer
Background As engineered biological systems become more complex, it is increasingly
common to express multiple operons from different plasmids and inducible expression systems …

Metabolic engineering of microbial pathways for advanced biofuels production

F Zhang, S Rodriguez, JD Keasling - Current opinion in biotechnology, 2011 - Elsevier
Production of biofuels from renewable resources such as cellulosic biomass provides a source
of liquid transportation fuel to replace petroleum-based fuels. This endeavor requires the …

Microbially synthesized polymeric amyloid fiber promotes β-nanocrystal formation and displays gigapascal tensile strength

J Li, Y Zhu, H Yu, B Dai, YS Jun, F Zhang - ACS nano, 2021 - ACS Publications
The ability of amyloid proteins to form stable β-sheet nanofibrils has made them potential
candidates for material innovation in nanotechnology. However, such a nanoscale feature has …

Spectral tuning of azobenzene photoswitches for biological applications

O Sadovski, AA Beharry, F Zhang… - Angewandte Chemie …, 2009 - Wiley Online Library
Longer switching wavelengths and good photochemical yields and stabilities of the cis
isomers in reducing aqueous environments are achieved by introducing 2,2′‐aminoalkyl …