… Organoid cultures of b, c, d CAM277 and f, g, h CAM338 were continually cultured and …
c, g Number of total mutations and mutated cancer-related genes from individual subclones. …

… Font color denotes tissue types, same as in (G). … (G) Fluorescence imaging of GFP indicating
successful transduction of organoids. Ctr, control. (H) Marker genes highly expressed in BE …

Esophageal adenocarcinoma (EAC) is a poor-prognosis cancer type with rapidly rising
incidence. Understanding of the genetic events driving EAC development is limited, and there …

… G. Devonshire reports grants from Cancer Research UK during the conduct of the study. M.
di Pietro reports grants from the Medical Research Council during the conduct of the study. …

Background & Aims Most patients with esophageal adenocarcinoma (EAC) present with de
novo tumors. Although this could be due to inadequate screening strategies, the precise …

Background & Aims Esophageal adenocarcinomas (EACs) are heterogeneous and often
preceded by Barrett’s esophagus (BE). Many genomic changes have been associated with …

Background The incidence of esophageal adenocarcinoma (EAC) is rapidly rising and has
a 5-year survival rate of <20%. Beyond TNM (tumor–node–metastasis) staging, no reliable …

Barrett’s esophagus is a pre-malignant lesion that can progress to esophageal adenocarcinoma.
We perform a multi-omic analysis of pre-cancer samples from 146 patients with a range …

Oesophageal adenocarcinoma (OAC) provides an ideal case study to characterize large-scale
rearrangements. Using whole genome short-read sequencing of 383 cases, for which …

Cancers occurring at the gastroesophageal junction (GEJ) are classified as predominantly
esophageal or gastric, which is often difficult to decipher. We hypothesized that the …