Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type
We describe convergent evidence from transcriptomics, morphology, and physiology for a
specialized GABAergic neuron subtype in human cortex. Using unbiased single-nucleus RNA …
specialized GABAergic neuron subtype in human cortex. Using unbiased single-nucleus RNA …
Unexpected effects of peripherally administered kynurenic acid on cortical spreading depression and related blood–brain barrier permeability
G Oláh, J Herédi, Á Menyhárt, Z Czinege… - Drug design …, 2013 - Taylor & Francis
Cortical spreading depression (CSD) involves a slowly-propagating depolarization wave in
the cortex, which can appear in numerous pathophysiological conditions, such as migraine …
the cortex, which can appear in numerous pathophysiological conditions, such as migraine …
Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex
…, D McMillen, EJ Melief, N Mihut, L Ng, J Nyhus, G Oláh… - Science, 2023 - science.org
Neocortical layer 1 (L1) is a site of convergence between pyramidal-neuron dendrites and
feedback axons where local inhibitory signaling can profoundly shape cortical processing. …
feedback axons where local inhibitory signaling can profoundly shape cortical processing. …
[HTML][HTML] Automatic deep learning-driven label-free image-guided patch clamp system
Patch clamp recording of neurons is a labor-intensive and time-consuming procedure. Here,
we demonstrate a tool that fully automatically performs electrophysiological recordings in …
we demonstrate a tool that fully automatically performs electrophysiological recordings in …
[HTML][HTML] Human neocortical expansion involves glutamatergic neuron diversification
The neocortex is disproportionately expanded in human compared with mouse 1 , 2 , both
in its total volume relative to subcortical structures and in the proportion occupied by …
in its total volume relative to subcortical structures and in the proportion occupied by …
Predominantly linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons
Summation of ionotropic receptor-mediated responses is critical in neuronal computation by
shaping input-output characteristics of neurons. However, arithmetics of summation for …
shaping input-output characteristics of neurons. However, arithmetics of summation for …
[HTML][HTML] Human neuronal changes in brain edema and increased intracranial pressure
Functional and molecular changes associated with pathophysiological conditions are
relatively easily detected based on tissue samples collected from patients. Population specific …
relatively easily detected based on tissue samples collected from patients. Population specific …
Temporal disparity of action potentials triggered in axon initial segments and distal axons in the neocortex
Neural population activity determines the timing of synaptic inputs, which arrive to dendrites,
cell bodies, and axon initial segments (AISs) of cortical neurons. Action potential initiation in …
cell bodies, and axon initial segments (AISs) of cortical neurons. Action potential initiation in …
Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons
The neocortex is disproportionately expanded in human compared to mouse, both in its total
volume relative to subcortical structures and in the proportion occupied by supragranular …
volume relative to subcortical structures and in the proportion occupied by supragranular …
Acetyl-L-carnitine normalizes the impaired long-term potentiation and spine density in a rat model of global ischemia
K Kocsis, L Knapp, L Gellért, G Oláh, ZS Kis… - Neuroscience, 2014 - Elsevier
As a consequence of an ischemic episode, energy production is disturbed, leading to neuronal
cell death. Despite intensive research, the quest for promising neuroprotective drugs has …
cell death. Despite intensive research, the quest for promising neuroprotective drugs has …