Objective To evaluate the prevalence and predictive value of anti–cyclic citrullinated peptide
(anti‐CCP) antibodies in individuals who subsequently developed rheumatoid arthritis (RA) …

Background Dietary fibre is thought to protect against colorectal cancer but this view has been
challenged by recent prospective and intervention studies that showed no protective effect…

Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

Background: Current evidence suggests that high red meat intake is associated with increased
colorectal cancer risk. High fish intake may be associated with a decreased risk, but the …

Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …

The evidence for anthropometric factors influencing breast cancer risk is accumulating, but
uncertainties remain concerning the role of fat distribution and potential effect modifiers. We …

Background Oncogenic human papillomaviruses (HPVs), especially HPV type 16 (HPV-16),
cause anogenital epithelial cancers and are suspected of causing epithelial cancers of the …

Background Saturated fatty acid (SFA) intake increases plasma LDL-cholesterol concentrations;
therefore, intake should be reduced to prevent coronary heart disease (CHD). Lower …

Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …

Background Infection with the human papillomavirus (HPV) has been established as a cause
of cervical cancer, but the association between a positive test for HPV DNA and the risk of …