Developmental programs that generate the astonishing neuronal diversity of the nervous
system are not completely understood and thus present a major challenge for clinical …

Direct cell programming via overexpression of transcription factors (TFs) aims to control cell
fate with the degree of precision needed for clinical applications. However, the regulatory …

Measuring cell identity in development, disease, and reprogramming is challenging as cell
types and states are in continual transition. Here, we present Capybara, a computational tool …

The Drosophila mutant tko 25t exhibits a deficiency of mitochondrial protein synthesis,
leading to a global insufficiency of respiration and oxidative phosphorylation. This entrains an …

The development of dendritic cells (DCs), including antigen-presenting conventional DCs (cDCs)
and cytokine-producing plasmacytoid DCs (pDCs), is controlled by the growth factor …

Neurogenins are proneural transcription factors required to specify neuronal identity. Their
overexpression in human pluripotent stem cells rapidly produces cortical-like neurons with …

Mitochondrial biogenesis is regulated by signaling pathways sensitive to extracellular conditions
and to the internal environment of the cell. Therefore, treatments for disease caused by …

In pluripotent cells, a delicate activation-repression balance maintains pro-differentiation
genes ready for rapid activation. The identity of transcription factors (TFs) that specifically …

Damage to the mitochondrial genome (mtDNA) can lead to diseases for which there are no
clearly effective treatments. Since mitochondrial function and biogenesis are controlled by …

Genetic and microscopic approaches using Saccharomyces cerevisiae have identified many
proteins that play a role in mitochondrial dynamics, but it is possible that other proteins and …