Background The automated reconstruction of genome sequences in ancient genome analysis
is a multifaceted process. Results Here we introduce EAGER, a time-efficient pipeline, …

Leprosy was endemic in Europe until the Middle Ages. Using DNA array capture, we have
obtained genome sequences of Mycobacterium leprae from skeletons of five medieval …

The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century
established this devastating infectious disease as one of the most feared in human history 1. …

Microbial producers such as Escherichia coli are evolutionarily trained to adapt to changing
substrate availabilities. Being exposed to large-scale production conditions, their complex, …

High-risk human papillomaviruses (hr-HPV) establish persistent infections in keratinocytes,
which can lead to cancer of the anogenital tract. Interferons (IFNs) are a family of secreted …

In large‐scale production processes, metabolic control is typically achieved by limited supply
of essential nutrients such as glucose or ammonia. With increasing bioreactor dimensions, …

Background: Radiofrequency ablation (RFA) is an established treatment option for malignancies
located in the liver. RFA-induced irreversible coagulation necrosis leads to the release …

The protease activity of the paracaspase mucosa-associated lymphoid tissue lymphoma
translocation gene 1 (MALT1) plays an important role in antigen receptor-mediated lymphocyte …

DNA capture coupled with next generation sequencing is highly suitable for the study of
ancient pathogens. Screening for pathogens can, however, be meticulous when assays are …

Motivation: The number of completely sequenced genomes is continuously rising, allowing
for comparative analyses of genomic variation. Such analyses are often based on whole-…