Over the past two decades, the domains of both frontline synthetic organic chemistry and
process chemistry have seen an increase in crosstalk between asymmetric organic/…

How changes in enzyme structure and dynamics facilitate passage along the reaction
coordinate is a fundamental unanswered question. Here, we use time-resolved mix-and-inject …

An NADP-dependent alcohol dehydrogenase from Clostridium acetobutylicum (CaADH) has
been expressed and characterized. CaADH enantioselectively reduces aromatic α-, β- and …

Described is an efficient stereocontrolled route into valuable, densely functionalized
fluorinated phosphonates that takes advantage of (i) a Clostridial enzyme to set the absolute …

There is currently great interest in human serine racemase, the enzyme responsible for
producing the NMDA co-agonist d-serine. Reported correlation of d-serine levels with disorders …

Herein we describe a formal thiocyanopalladation/carbocyclization transformation and its
parametrization and optimization using a new elevated temperature plate-based version of our …

… “Solid” indicates a large area of GA without central sparing within the GA, although the GA
itself could be extrafoveal. (The horseshoe, ring, and solid groups include eyes in which there …

… eyes with GA and VA greater than or equal to 20/50 from a prospective natural history study
of GA were … for the GA group. Contrast sensitivity was significantly reduced for the eyes with …

… 35 patients with GA and 10 eyes of 5 patients with Stargardt disease. The patients with GA
also … Results: Sixty-three percent of GA eyes fixating outside the atrophy placed the scotoma to …

… studies concentrated on GA, and few eyes with GA were included. Other studies of GA have
… Ninety-one of the enrolled patients (bilateral GA group) had bilateral GA without evidence of …