User profiles for G. A. McLaughlin

Grace McLaughlin

University of North Carolina at Chapel Hill
Verified email at live.unc.edu
Cited by 848

mRNA structure determines specificity of a polyQ-driven phase separation

EM Langdon, Y Qiu, A Ghanbari Niaki, GA McLaughlin… - Science, 2018 - science.org
RNA promotes liquid-liquid phase separation (LLPS) to build membraneless compartments
in cells. How distinct molecular compositions are established and maintained in these liquid …

[PDF][PDF] Genomic RNA elements drive phase separation of the SARS-CoV-2 nucleocapsid

…, MA Boerneke, RSG Sealfon, GA McLaughlin… - Molecular cell, 2020 - cell.com
We report that the SARS-CoV-2 nucleocapsid protein (N-protein) undergoes liquid-liquid
phase separation (LLPS) with viral RNA. N-protein condenses with specific RNA genomic …

Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures

…, I Seim, M Lee, R Sealfon, GA McLaughlin… - Nucleic acids …, 2022 - academic.oup.com
Nucleocapsid protein (N-protein) is required for multiple steps in betacoronaviruses replication.
SARS-CoV-2-N-protein condenses with specific viral RNAs at particular temperatures …

History of pyrethrum

GA McLAUGHLIN - Pyrethrum; The Natural Insecticide, 1973 - books.google.com
… It is interesting to note that MGK, incorporated in 1908 as McLaughlin Cormley King
Company, an importer and miller of botanical materials, was dealing with insect flowers in 1915. …

Phosphoregulation provides specificity to biomolecular condensates in the cell cycle and cell polarity

TM Gerbich, GA McLaughlin, K Cassidy… - Journal of Cell …, 2020 - rupress.org
Biomolecular condensation is a way of organizing cytosol in which proteins and nucleic acids
coassemble into compartments. In the multinucleate filamentous fungus Ashbya gossypii, …

Spatial heterogeneity of the cytosol revealed by machine learning-based 3D particle tracking

GA McLaughlin, EM Langdon… - Molecular biology of …, 2020 - Am Soc Cell Biol
The spatial structure and physical properties of the cytosol are not well understood.
Measurements of the material state of the cytosol are challenging due to its spatial and temporal …

The dielectric constant of phospholipid bilayers and the permeability of membranes to ions

JP Dilger, SGA McLaughlin, TJ McIntosh, SA Simon - Science, 1979 - science.org
The Born charging equation predicts that the permeability of a phospholipid bilayer membrane
to ions should depend markedly on the dielectric constant of the membrane. Increasing …

Role of alcohol dehydrogenase in the swift increase in alcohol metabolism (SIAM): studies with deermice deficient in alcohol dehydrogenase

EB Glassman, GA McLaughlin, DT Forman… - Biochemical …, 1985 - Elsevier
Previous studies have shown that rates of ethanol metabolism increase markedly 2–4 hr after
the administration of ethanol in rats and in four inbred strains of mice. This phenomenon, …

[HTML][HTML] Biomolecular condensates in fungi are tuned to function at specific temperatures

BM Stormo, GA McLaughlin, LK Frederick, AP Jalihal… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Temperature can impact every reaction and molecular interaction essential to a cell. For
organisms that cannot regulate their own temperature, a major challenge is how to adapt to …

The electrostatic properties of membranes

S McLaughlin - Annual review of biophysics and biophysical …, 1989 - annualreviews.org
McLaughlin, unpublished observations) probes when the membranes conн tained a polyvalent
lipid such as PIP2• In summary, one can assume that the charges on monovalent lipids (…