[HTML][HTML] Improved reference genome of Aedes aegypti informs arbovirus vector control

…, M Herre, SN Redmond, NH Rose, GD Weedall… - Nature, 2018 - nature.com
Female Aedes aegypti mosquitoes infect more than 400 million people each year with
dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in …

[HTML][HTML] Rise of multiple insecticide resistance in Anopheles funestus in Malawi: a major concern for malaria vector control

…, KG Barnes, H Irving, SS Ibrahim, GD Weedall… - Malaria journal, 2015 - Springer
Background Deciphering the dynamics and evolution of insecticide resistance in malaria
vectors is crucial for successful vector control. This study reports an increase of resistance …

A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing insecticide-treated bednet efficacy

GD Weedall, LMJ Mugenzi, BD Menze… - Science translational …, 2019 - science.org
… In a new study, Weedall et al. detected the major genes conferring insecticide resistance
on the Anopheles mosquito vector of malaria in Africa. They found a DNA marker in a gene (…

Detecting signatures of balancing selection to identify targets of anti-parasite immunity

GD Weedall, DJ Conway - Trends in parasitology, 2010 - cell.com
Parasite antigen genes might evolve under frequency-dependent immune selection. The
distinctive patterns of polymorphism that result can be detected using population genetic …

[HTML][HTML] The genome and transcriptome of the enteric parasite Entamoeba invadens, a model for encystation

GM Ehrenkaufer, GD Weedall, D Williams, HA Lorenzi… - Genome biology, 2013 - Springer
Background Several eukaryotic parasites form cysts that transmit infection. The process is
found in diverse organisms such as Toxoplasma, Giardia, and nematodes. In Entamoeba …

[HTML][HTML] Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus

…, H Irving, M Tchoupo, J Hearn, GD Weedall… - Nature …, 2019 - nature.com
Elucidating the genetic basis of metabolic resistance to insecticides in malaria vectors is
crucial to prolonging the effectiveness of insecticide-based control tools including long lasting …

[HTML][HTML] Prospective identification of malaria parasite genes under balancing selection

…, AW Thomas, K Marsh, GD Weedall… - PloS one, 2009 - journals.plos.org
Background Endemic human pathogens are subject to strong immune selection, and
interrogation of pathogen genome variation for signatures of balancing selection can identify …

[HTML][HTML] An Africa-wide genomic evolution of insecticide resistance in the malaria vector Anopheles funestus involves selective sweeps, copy number variations, gene …

GD Weedall, JM Riveron, J Hearn, H Irving… - PLoS …, 2020 - journals.plos.org
Insecticide resistance in malaria vectors threatens to reverse recent gains in malaria control.
Deciphering patterns of gene flow and resistance evolution in malaria vectors is crucial to …

[HTML][HTML] Genomic footprints of selective sweeps from metabolic resistance to pyrethroids in African malaria vectors are driven by scale up of insecticide-based vector …

KG Barnes, GD Weedall, M Ndula, H Irving… - PLoS …, 2017 - journals.plos.org
Insecticide resistance in mosquito populations threatens recent successes in malaria
prevention. Elucidating patterns of genetic structure in malaria vectors to predict the speed and …

Host–Parasite interactions in Entamoeba histolytica and Entamoeba dispar: what have we learned from their genomes?

IW Wilson, GD Weedall, N Hall - Parasite Immunology, 2012 - Wiley Online Library
Invasive amoebiasis caused by Entamoeba histolytica is a major global health problem.
Virulence is a rare outcome of infection, occurring in fewer than 1 in 10 infections. Not all strains …