[HTML][HTML] Improved reference genome of Aedes aegypti informs arbovirus vector control
Female Aedes aegypti mosquitoes infect more than 400 million people each year with
dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in …
dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in …
[HTML][HTML] Rise of multiple insecticide resistance in Anopheles funestus in Malawi: a major concern for malaria vector control
…, KG Barnes, H Irving, SS Ibrahim, GD Weedall… - Malaria journal, 2015 - Springer
Background Deciphering the dynamics and evolution of insecticide resistance in malaria
vectors is crucial for successful vector control. This study reports an increase of resistance …
vectors is crucial for successful vector control. This study reports an increase of resistance …
A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing insecticide-treated bednet efficacy
GD Weedall, LMJ Mugenzi, BD Menze… - Science translational …, 2019 - science.org
… In a new study, Weedall et al. detected the major genes conferring insecticide resistance
on the Anopheles mosquito vector of malaria in Africa. They found a DNA marker in a gene (…
on the Anopheles mosquito vector of malaria in Africa. They found a DNA marker in a gene (…
Detecting signatures of balancing selection to identify targets of anti-parasite immunity
GD Weedall, DJ Conway - Trends in parasitology, 2010 - cell.com
Parasite antigen genes might evolve under frequency-dependent immune selection. The
distinctive patterns of polymorphism that result can be detected using population genetic …
distinctive patterns of polymorphism that result can be detected using population genetic …
[HTML][HTML] The genome and transcriptome of the enteric parasite Entamoeba invadens, a model for encystation
GM Ehrenkaufer, GD Weedall, D Williams, HA Lorenzi… - Genome biology, 2013 - Springer
Background Several eukaryotic parasites form cysts that transmit infection. The process is
found in diverse organisms such as Toxoplasma, Giardia, and nematodes. In Entamoeba …
found in diverse organisms such as Toxoplasma, Giardia, and nematodes. In Entamoeba …
[HTML][HTML] Cis-regulatory CYP6P9b P450 variants associated with loss of insecticide-treated bed net efficacy against Anopheles funestus
…, H Irving, M Tchoupo, J Hearn, GD Weedall… - Nature …, 2019 - nature.com
Elucidating the genetic basis of metabolic resistance to insecticides in malaria vectors is
crucial to prolonging the effectiveness of insecticide-based control tools including long lasting …
crucial to prolonging the effectiveness of insecticide-based control tools including long lasting …
[HTML][HTML] Prospective identification of malaria parasite genes under balancing selection
…, AW Thomas, K Marsh, GD Weedall… - PloS one, 2009 - journals.plos.org
Background Endemic human pathogens are subject to strong immune selection, and
interrogation of pathogen genome variation for signatures of balancing selection can identify …
interrogation of pathogen genome variation for signatures of balancing selection can identify …
[HTML][HTML] An Africa-wide genomic evolution of insecticide resistance in the malaria vector Anopheles funestus involves selective sweeps, copy number variations, gene …
GD Weedall, JM Riveron, J Hearn, H Irving… - PLoS …, 2020 - journals.plos.org
Insecticide resistance in malaria vectors threatens to reverse recent gains in malaria control.
Deciphering patterns of gene flow and resistance evolution in malaria vectors is crucial to …
Deciphering patterns of gene flow and resistance evolution in malaria vectors is crucial to …
[HTML][HTML] Genomic footprints of selective sweeps from metabolic resistance to pyrethroids in African malaria vectors are driven by scale up of insecticide-based vector …
KG Barnes, GD Weedall, M Ndula, H Irving… - PLoS …, 2017 - journals.plos.org
Insecticide resistance in mosquito populations threatens recent successes in malaria
prevention. Elucidating patterns of genetic structure in malaria vectors to predict the speed and …
prevention. Elucidating patterns of genetic structure in malaria vectors to predict the speed and …
Host–Parasite interactions in Entamoeba histolytica and Entamoeba dispar: what have we learned from their genomes?
IW Wilson, GD Weedall, N Hall - Parasite Immunology, 2012 - Wiley Online Library
Invasive amoebiasis caused by Entamoeba histolytica is a major global health problem.
Virulence is a rare outcome of infection, occurring in fewer than 1 in 10 infections. Not all strains …
Virulence is a rare outcome of infection, occurring in fewer than 1 in 10 infections. Not all strains …