Background The incidence and severity of herpes zoster and postherpetic neuralgia increase
with age in association with a progressive decline in cell-mediated immunity to varicella–…

Eukaryotic gene transcription is accompanied by acetylation and methylation of nucleosomes
near promoters, but the locations and roles of histone modifications elsewhere in the …

DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned
the discovery of all classes of cis-regulatory elements including enhancers, promoters, …

The human body is composed of diverse cell types with distinct functions. Although it is
known that lineage specification depends on cell-specific gene expression, which in turn is …

The ENCyclopedia Of DNA Elements (ENCODE) Project aims to identify all functional elements
in the human genome sequence. The pilot phase of the Project is focused on a specified …

Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Technologies that enable targeted manipulation of epigenetic marks could be used to
precisely control cell phenotype or interrogate the relationship between the epigenome and …

Mapping DNase I hypersensitive (HS) sites is an accurate method of identifying the location
of genetic regulatory elements, including promoters, enhancers, silencers, insulators, and …

Technologies for engineering synthetic transcription factors have enabled many advances
in medical and scientific research. In contrast to existing methods based on engineering of …

INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …