The aspartyl protease BACE1 cleaves the amyloid precursor protein and the sialyltransferase
ST6Gal I and is important in the pathogenesis of Alzheimer's disease. The normal function …

The development of molecular probes that allow in vivo imaging of neural signaling processes
with high temporal and spatial resolution remains challenging. Here we applied directed …

A prominent goal of neuroscience is to improve our understanding of how brain structure
and activity interact to produce perception, emotion, behavior, and cognition. The brain’s …

Non-invasive observation of spatiotemporal activity of large neural populations distributed
over entire brains is a longstanding goal of neuroscience. We developed a volumetric …

We introduce a selective and cell-permeable calcium sensor for photoacoustics (CaSPA), a
versatile imaging technique that allows for fast volumetric mapping of photoabsorbing …

We genetically controlled compartmentalization in eukaryotic cells by heterologous
expression of bacterial encapsulin shell and cargo proteins to engineer enclosed enzymatic …

Bacteriophages are potent therapeutics against biohazardous bacteria, which rapidly develop
multidrug resistance. However, routine administration of phage therapy is hampered by a …

While genetically encoded reporters are common for fluorescence microscopy, equivalent
multiplexable gene reporters for electron microscopy (EM) are still scarce. Here, by installing a …

… We are grateful to members of the Shapiro and Westmeyer laboratories for helpful discussions.
Relevant research in the Shapiro laboratory was supported by the National Institutes of …

Cleavage of the β-amyloid precursor protein (APP) by the aspartyl protease β-site APP-cleaving
enzyme (BACE) is the first step in the generation of the amyloid β-peptide, which is …