User profiles for G. I. Lang
Gregory I. LangAssociate Professor, Department of Biological Sciences, Lehigh University Verified email at lehigh.edu Cited by 2221 |
Pervasive genetic hitchhiking and clonal interference in forty evolving yeast populations
The dynamics of adaptation determine which mutations fix in a population, and hence how
reproducible evolution will be. This is central to understanding the spectra of mutations …
reproducible evolution will be. This is central to understanding the spectra of mutations …
[HTML][HTML] The spectrum of adaptive mutations in experimental evolution
A primary goal of recent work in experimental evolution is to probe the molecular basis of
adaptation. This requires an understanding of the individual mutations in evolving populations: …
adaptation. This requires an understanding of the individual mutations in evolving populations: …
Estimating the Per-Base-Pair Mutation Rate in the Yeast Saccharomyces cerevisiae
Although mutation rates are a key determinant of the rate of evolution they are difficult to
measure precisely and global mutations rates (mutations per genome per generation) are often …
measure precisely and global mutations rates (mutations per genome per generation) are often …
Genetic variation and the fate of beneficial mutations in asexual populations
… our previous observation that, in yeast, mutations in any one of several genes that eliminate
the ability to mate provide a fitness advantage during long-term asexual propagation (Lang …
the ability to mate provide a fitness advantage during long-term asexual propagation (Lang …
The cost of gene expression underlies a fitness trade-off in yeast
Natural selection optimizes an organism's genotype within the context of its environment.
Adaptations to one environment can decrease fitness in another, revealing evolutionary trade-…
Adaptations to one environment can decrease fitness in another, revealing evolutionary trade-…
Mutation rates across budding yeast chromosome VI are correlated with replication timing
Previous experimental studies suggest that the mutation rate is nonuniform across the yeast
genome. To characterize this variation across the genome more precisely, we measured the …
genome. To characterize this variation across the genome more precisely, we measured the …
Mutation rates, spectra, and genome-wide distribution of spontaneous mutations in mismatch repair deficient yeast
DNA mismatch repair is a highly conserved DNA repair pathway. In humans, germline
mutations in hMSH2 or hMLH1, key components of mismatch repair, have been associated with …
mutations in hMSH2 or hMLH1, key components of mismatch repair, have been associated with …
Experimental evolution in fungi: An untapped resource
Historically, evolutionary biology has been considered an observational science. Examining
populations and inferring evolutionary histories mold evolutionary theories. In contrast, …
populations and inferring evolutionary histories mold evolutionary theories. In contrast, …
[HTML][HTML] Adaptive genome duplication affects patterns of molecular evolution in Saccharomyces cerevisiae
… Buskirk SW, Peace RE, Lang GI. Hitchhiking and epistasis give rise to cohort dynamics in
adapting populations. Proceedings of the National Academy of Sciences 2017 August 01;114(…
adapting populations. Proceedings of the National Academy of Sciences 2017 August 01;114(…
Identifying targets of selection in laboratory evolution experiments
AA Martínez, GI Lang - Journal of Molecular Evolution, 2023 - Springer
Adaptive evolution navigates a balance between chance and determinism. The stochastic
processes of mutation and drift generate phenotypic variation; however, once mutations reach …
processes of mutation and drift generate phenotypic variation; however, once mutations reach …