User profiles for G. J. Murphy

Gavin Murphy

- Verified email at le.ac.uk - Cited by 9847

Gabe J Murphy

- Verified email at fredhutch.org - Cited by 4406

George J. Murphy

- Verified email at bu.edu - Cited by 4062

PPAR-γ agonists: therapeutic role in diabetes, inflammation and cancer

GJ Murphy, JC Holder - Trends in pharmacological sciences, 2000 - cell.com
The recent development of a novel class of insulin-sensitizing drugs, the thiazolidinediones (TZDs),
represents a significant advance in antidiabetic therapy. One key mechanism by …

[HTML][HTML] Universal definition of perioperative bleeding in adult cardiac surgery

…, A Hofmann, K Karkouti, M Levi, GJ Murphy… - The Journal of thoracic …, 2014 - Elsevier
Objectives Perioperative bleeding is common among patients undergoing cardiac surgery;
however, the definition of perioperative bleeding is variable and lacks standardization. We …

Side effects of cardiopulmonary bypass: what is the reality?

GJ Murphy, GD Angelini - Journal of cardiac surgery, 2004 - Wiley Online Library
Despite many years of clinical and experimental research, the contribution of cardiopulmonary
bypass (CPB) and cardioplegic arrest to morbidity and mortality following cardiac surgery …

[BOOK][B] C*-algebras and operator theory

GJ Murphy - 2014 - books.google.com
This book constitutes a first-or second-year graduate course in operator theory. It is a field
that has great importance for other areas of mathematics and physics, such as algebraic …

Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery

GJ Murphy, BC Reeves, CA Rogers, SIA Rizvi… - Circulation, 2007 - Am Heart Assoc
Background— Red blood cell transfusion can both benefit and harm. To inform decisions
about transfusion, we aimed to quantify associations of transfusion with clinical outcomes and …

[PDF][PDF] Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

…, JW Yates, NJ Pearce, OL Rausch, GJ Murphy… - Chemistry & biology, 2000 - cell.com
Background: Glycogen synthase kinase-3 (GSK-3) is a serine/threonine protein kinase, the
activity of which is inhibited by a variety of extracellular stimuli including insulin, growth factors…

Induced pluripotent stem cell generation using a single lentiviral stem cell cassette

CA Sommer, M Stadtfeld, GJ Murphy… - Stem …, 2009 - academic.oup.com
Induced pluripotent stem (iPS) cells can be generated using retroviral vectors expressing
Oct4, Klf4, Sox2, and cMyc. Most prior studies have required multiple retroviral vectors for …

[HTML][HTML] Liberal or restrictive transfusion after cardiac surgery

GJ Murphy, K Pike, CA Rogers… - … England Journal of …, 2015 - Mass Medical Soc
Background Whether a restrictive threshold for hemoglobin level in red-cell transfusions, as
compared with a liberal threshold, reduces postoperative morbidity and health care costs …

[PDF][PDF] A suite of transgenic driver and reporter mouse lines with enhanced brain-cell-type targeting and functionality

…, SM Sunkin, J Lecoq, MZ Lin, ES Boyden, GJ Murphy… - Cell, 2018 - cell.com
Modern genetic approaches are powerful in providing access to diverse cell types in the brain
and facilitating the study of their function. Here, we report a large set of driver and reporter …

[PDF][PDF] Integrated morphoelectric and transcriptomic classification of cortical GABAergic cells

…, ES Lein, C Koch, Z Yao, B Tasic, J Berg, GJ Murphy… - Cell, 2020 - cell.com
Neurons are frequently classified into distinct types on the basis of structural, physiological,
or genetic attributes. To better constrain the definition of neuronal cell types, we …