Bacterial skin infections represent some of the most common infectious diseases globally.
Prevention and treatment of skin infections can involve application of a topical antimicrobial, …

The worldwide emergence of epidemic strains of Clostridium difficile linked to increased
disease severity and mortality has resulted in greater research efforts toward determining the …

During the past decade, there has been a striking increase in Clostridium difficile nosocomial
infections worldwide predominantly due to the emergence of epidemic or hypervirulent …

Clostridium difficile is the leading cause of infectious diarrhoea in hospitals worldwide,
because of its virulence, spore-forming ability and persistence 1 , 2 . C. difficile-associated …

Progress in exploiting clostridial genome information has been severely impeded by a general
lack of effective methods for the directed inactivation of specific genes. Those few mutants …

Clostridium difficile is a leading cause of antibiotic-associated diarrhea, a significant animal
pathogen, and a worldwide public health burden. Most disease-causing strains secrete two …

Alcohol-based disinfectants and particularly hand rubs are a key way to control hospital
infections worldwide. Such disinfectants restrict transmission of pathogens, such as multidrug-…

Clostridium difficile binary toxin (CDT) is an actin-specific ADP-ribosyltransferase that is
produced by various C. difficile isolates, including the “hypervirulent” NAP1/027 epidemic strains…

FIRST described as a human pathogen 50 years ago, 1 Yersinia enterocolitica has become
a major cause of diarrhea in much of the industrialized world. In Scandinavia, Japan, …

Nosocomial infections are increasingly being recognised as a major patient safety issue. The
modern hospital environment and associated health care practices have provided a niche …