Protein silencing is often employed as a means to aid investigations in protein function and
is increasingly desired as a therapeutic approach. Several types of protein silencing …

SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß)
family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in …

Xanthine oxidase (XO) was shown to catalyze the reduction of nitrite to nitric oxide (NO), under
anaerobic conditions, in the presence of either NADH or xanthine as reducing substrate. …

The LKB1 gene encodes a serine/threonine kinase mutated in Peutz–Jeghers cancer
syndrome. Despite several proposed models for LKB1 function in development and in tumour …

Targeted protein degradation (TPD) is an emerging modality for research and therapeutics.
Most TPD approaches harness cellular ubiquitin-dependent proteolytic pathways. Proteolysis…

The role of the protein kinase Akt in cell migration is incompletely understood. Here we show
that sphingosine-1-phosphate (S1P)-induced endothelial cell migration requires the Akt-…

Hormones and growth factors induce the activation of a number of protein kinases that
belong to the AGC subfamily, including isoforms of PKA, protein kinase B (also known as Akt), …

Small molecule inhibitors of type 1 receptor serine threonine kinases (ALKs1-7), the mediators
of TGFß and BMP signals, have been employed extensively to assess their physiological …

Peutz-Jeghers syndrome is an inherited cancer syndrome that results in a greatly increased
risk of developing tumors in those affected. The causative gene is a protein kinase termed …

The DNA-dependent protein kinase (DNA-PK) is required for the repair of DNA double-strand
breaks (DSBs), such as those caused by ionizing radiation and other DNA-damaging …