User profiles for G. R. Sliwoski
 | Gregory SliwoskiVanderbilt University Verified email at vanderbilt.edu Cited by 2681 |
An Acquired HER2 T798I Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant–Driven Breast Cancer
…, MR Brewer, JH Sheehan, JP Koch, GR Sliwoski… - Cancer discovery, 2017 - AACR
We report a HER2 T798I gatekeeper mutation in a patient with HER2 L869R -mutant breast
cancer with acquired resistance to neratinib. Laboratory studies suggested that HER2 …
cancer with acquired resistance to neratinib. Laboratory studies suggested that HER2 …
[HTML][HTML] Clozapine interaction with phosphatidyl inositol 3-kinase (PI3K)/insulin-signaling pathway in Caenorhabditis elegans
R Karmacharya, GR Sliwoski, MY Lundy… - …, 2009 - nature.com
Clozapine has superior and unique effects as an antipsychotic agent, but the mediators of
these effects are not known. We studied behavioral and developmental effects of clozapine in …
these effects are not known. We studied behavioral and developmental effects of clozapine in …
[HTML][HTML] Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket
X Pedragosa-Badia, GR Sliwoski, ED Nguyen… - Journal of Biological …, 2014 - ASBMB
Structural characterization of the human Y 4 receptor (hY 4 R) interaction with human pancreatic
polypeptide (hPP) is crucial, not only for understanding its biological function but also …
polypeptide (hPP) is crucial, not only for understanding its biological function but also …
[HTML][HTML] A Genome-Wide RNAi Screen in Caenorhabditis elegans Identifies the Nicotinic Acetylcholine Receptor Subunit ACR-7 as an Antipsychotic Drug Target
T Saur, SE DeMarco, A Ortiz, GR Sliwoski, L Hao… - PLoS …, 2013 - journals.plos.org
We report a genome-wide RNA interference (RNAi) screen for Suppressors of Clozapine-induced
Larval Arrest (scla genes) in Caenorhabditis elegans, the first genetic suppressor …
Larval Arrest (scla genes) in Caenorhabditis elegans, the first genetic suppressor …
[HTML][HTML] PSCAN: Spatial scan tests guided by protein structures improve complex disease gene discovery and signal variant detection
Germline disease-causing variants are generally more spatially clustered in protein 3-dimensional
structures than benign variants. Motivated by this tendency, we develop a fast and …
structures than benign variants. Motivated by this tendency, we develop a fast and …
The Relevance ofCaenorhabditis elegansGenetics for Understanding Human Psychiatric Disease
X Wang, GR Sliwoski, EA Buttner - Harvard Review of Psychiatry, 2011 - journals.lww.com
How mutations in human genes cause disease remains unclear in most cases. If we can
understand the molecular mechanisms through which specific genes cause or increase the risk …
understand the molecular mechanisms through which specific genes cause or increase the risk …
The impact of natural selection on the evolution and function of placentally expressed galectins
ZA Ely, JM Moon, GR Sliwoski… - Genome Biology and …, 2019 - academic.oup.com
Immunity genes have repeatedly experienced natural selection during mammalian evolution.
Galectins are carbohydrate-binding proteins that regulate diverse immune responses, …
Galectins are carbohydrate-binding proteins that regulate diverse immune responses, …
The impact of natural selection on the evolution and function of placentally expressed galectins
ZA Ely, JM Moon, GR Sliwoski, AK Sangha, XX Shen… - bioRxiv, 2018 - biorxiv.org
Immunity genes have repeatedly experienced natural selection during mammalian evolution.
Galectins are carbohydrate-binding proteins that regulate diverse immune responses, …
Galectins are carbohydrate-binding proteins that regulate diverse immune responses, …
3D enantioselective descriptors for ligand-based computer-aided drug design
GR Sliwoski - 2012 - ir.vanderbilt.edu
A novel three dimensional stereoselective descriptor for use in ligand-based computer-aided
drug design (CADD) is presented in this thesis. CADD is an important tool for drug …
drug design (CADD) is presented in this thesis. CADD is an important tool for drug …
[PDF][PDF] Pancreatic Polypeptide is Recognized by
…, D Lindner, JX Pedragosa-Badia, GR Sliwoski - 2013 - Citeseer
To whom the correspondence should be addressed: Annette G. Beck-Sickinger, Institute of
Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, Universität Leipzig, …
Biochemistry, Faculty of Biosciences, Pharmacy and Psychology, Universität Leipzig, …