Measures of substrate oxidation have traditionally been calculated from indirect calorimetry
measurements using stoichiometric equations. Although this has proven to be a solid …

… For the COLlAl gene and the proal(I) chain, the majority of mutations that give rise to exon
skipping eventsare either very severe or lethal46 47 (Wallis et al, unpublished data). Mild …

Objectives Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component.
To identify novel loci associated with hip OA we performed a meta-analysis of genome…

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

RES, PT, B. GROEN, B. PENNINGS, M. BEELEN, GA WALLIS, AP GIJSEN, JMG SENDEN,
and LJC VAN LOON. Protein Ingestion before Sleep Improves Postexercise Overnight …

Exercise confers protection against obesity, type 2 diabetes and other cardiometabolic
diseases 1 , 2 , 3 , 4 – 5 . However, the molecular and cellular mechanisms that mediate the …

Nicotinamide adenine dinucleotide (NAD + ) is modulated by conditions of metabolic stress
and has been reported to decline with aging in preclinical models, but human data are …

Objective To investigate the underlying mechanisms behind changes in glucose homeostasis
with delivery of propionate to the human colon by comprehensive and coordinated …

The currently accepted amount of protein required to achieve maximal stimulation of
myofibrillar protein synthesis ( MPS ) following resistance exercise is 20–25 g. However, the …

Background Oxidative stress is proposed as an important factor in osteoarthritis (OA).
Objective To investigate the expression of the three superoxide dismutase (SOD) antioxidant …