Cellular decision making is the process whereby cells assume different, functionally
important and heritable fates without an associated genetic or environmental difference. Such …

Defining the gene products that play an essential role in an organism's functional repertoire
is vital to understanding the system level organization of living cells. We used a genetic …

… Cultures were grown in synthetic dropout (SD) media (6.7 g L21 yeast nitrogen base without
amino acids, 1.92 g L21 dropout supplement without tryptophan, and 76 mg L21 adenine, …

Although several recent studies have focused on gene autoregulation, the effects of negative
feedback (NF) on gene expression are not fully understood. Our purpose here was to …

Intracellular pathogens such as Mycobacterium tuberculosis have evolved strategies for
coping with the pressures encountered inside host cells. The ability to coordinate global gene …

… Building on this work, Li and Balazsi (2018) developed an ODE model that coupled BACH1
and RKIP with EMT and stemness TFs/miRNAs. The coupled model had as steady states an …

… 4 E–G): promoter D12 has the highest levels of peak noise in the double operator set, followed
by promoter D13 which has higher peak noise than promoter D23, reflecting the distance …

Genetically identical cells frequently display substantial heterogeneity in gene expression,
cellular morphology and physiology. It has been suggested that by rapidly generating a …

… This research objective is sometimes called genotype to phenotype (G 2 P) or genotype to
fitness (G 2 F). But here, we prefer the term adaptation code, for it more broadly encompasses …

Recent evidence indicates that potential interactions within metabolic, protein–protein
interaction, and transcriptional regulatory networks are used differentially according to the …