Incubation of NAD + with extracts from sea urchin eggs resulted in production of a metabolite
which could mobilize intracellular Ca 2+ stores of the eggs. In this study we present …

Background DNA vaccination is known to generate immune responses against HIV-1 in
animal models. We aimed to assess the efficacy of DNA vaccination in induction of immune …

10.7554/eLife.11282.001 Many microbial populations rapidly adapt to changing environments
with multiple variants competing for survival. To quantify such complex evolutionary …

… A median of 14% (range 0–42%) of the DNA sequences were defective due to G-to-A
hypermutation. Remaining DNA sequences showed no evidence of evolution over years of …

Background. A human immunodeficiency virus (HIV) vaccine that limits disease and
transmission is urgently needed. This clinical trial evaluated the safety and immunogenicity of an …

… For HIV, G-to-A mutations are more common than other mutations. Thus, there is a higher
production rate of M184I than M184V since the wild-type methionine is coded ATG and the …

This article first compares differences in hearing-aid outcome for groups of older adults fitted
with different hearing-aid technologies, ranging from one-channel linear aids with output-…

Background: The two widely spread human polyomaviruses, BK virus (BKV) and JC virus (JCV)
establish latency in the urinary tract, and can be reactivated in AIDS. JCV might cause …

Perceived benefit, satisfaction, and hearing aid use patterns were measured in a follow-up
study to a large-scale multi-site clinical trial conducted in 1996–97. Measures included the …

ContextNumerous studies have demonstrated that hearing aids provide significant benefit for
a wide range of sensorineural hearing loss, but no carefully controlled, multicenter clinical …