User profiles for G. Bussotti
 | Giovanni BussottiVeracyte Verified email at veracyte.com Cited by 24953 |
Multiple sequence alignment modeling: methods and applications
This review provides an overview on the development of Multiple sequence alignment (MSA)
methods and their main applications. It is focused on progress made over the past decade. …
methods and their main applications. It is focused on progress made over the past decade. …
[HTML][HTML] A comparative encyclopedia of DNA elements in the mouse genome
The laboratory mouse shares the majority of its protein-coding genes with humans, making
it the premier model organism in biomedical research, yet the two mammals differ in …
it the premier model organism in biomedical research, yet the two mammals differ in …
The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression
The human genome contains many thousands of long noncoding RNAs (lncRNAs). While
several studies have demonstrated compelling biological and disease roles for individual …
several studies have demonstrated compelling biological and disease roles for individual …
[HTML][HTML] Long noncoding RNAs with enhancer-like function in human cells
…, M Beringer, K Gumireddy, A Gardini, G Bussotti… - Cell, 2010 - cell.com
While the long noncoding RNAs (ncRNAs) constitute a large portion of the mammalian
transcriptome, their biological functions has remained elusive. A few long ncRNAs that have been …
transcriptome, their biological functions has remained elusive. A few long ncRNAs that have been …
[HTML][HTML] CARMEN, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis
… Cell debris was removed by centrifugation at 4 C, precleared with Protein G dynal beads (Invitrogen)
before adding the respective antibodies pre-bound with Protein G dynal beads for 3 …
before adding the respective antibodies pre-bound with Protein G dynal beads for 3 …
Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing
We compared quantitative RT-PCR (qRT-PCR), RNA-seq and capture sequencing (CaptureSeq)
in terms of their ability to assemble and quantify long noncoding RNAs and novel …
in terms of their ability to assemble and quantify long noncoding RNAs and novel …
Modulation of Aneuploidy in Leishmania donovani during Adaptation to Different In Vitro and In Vivo Environments and Its Impact on Gene Expression
Aneuploidy is usually deleterious in multicellular organisms but appears to be tolerated and
potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major …
potentially beneficial in unicellular organisms, including pathogens. Leishmania, a major …
[HTML][HTML] Detecting and comparing non-coding RNAs in the high-throughput era
In recent years there has been a growing interest in the field of non-coding RNA. This surge
is a direct consequence of the discovery of a huge number of new non-coding genes and of …
is a direct consequence of the discovery of a huge number of new non-coding genes and of …
Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani
P Prieto Barja, P Pescher, G Bussotti… - Nature ecology & …, 2017 - nature.com
… a weight between 60 and 90 g. Housing of the animals and all … Homogenates were cleared
by centrifugation at 130 g for 5 … 5 min later by centrifugation at 2000 g for 10 min at 4 C. After …
by centrifugation at 130 g for 5 … 5 min later by centrifugation at 2000 g for 10 min at 4 C. After …
Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and …
G Bussotti, E Gouzelou, M Côrtes Boité, I Kherachi… - MBio, 2018 - Am Soc Microbiol
Protozoan parasites of the genus Leishmania adapt to environmental change through
chromosome and gene copy number variations. Only little is known about external or intrinsic …
chromosome and gene copy number variations. Only little is known about external or intrinsic …