Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope
glycoprotein are critical for viral evasion of antibody neutralization, and are themselves …

Respiratory syncytial virus (RSV) is the leading cause of hospitalization for children under 5
years of age. We sought to engineer a viral antigen that provides greater protection than …

… -PEG 2,000 -biotin (Avanti) was then added to the reaction at a final concentration of 6 μM
(0.02 mg ml −1 ), and the labelled virus was purified by ultracentrifugation for 1 h at 150,000g …

Numerous antibodies that neutralize SARS-CoV-2 have been identified, and these generally
target either the receptor-binding domain (RBD) or the N-terminal domain (NTD) of the viral …

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
in the Omicron lineage has resulted in diminished Coronavirus Disease 2019 (COVID-19) …

The SARS-CoV-2 spike employs mobile receptor-binding domains (RBDs) to engage the
human ACE2 receptor and to facilitate virus entry, which can occur through low-pH-endosomal …

SARS-CoV-2 Omicron is highly transmissible and has substantial resistance to neutralization
following immunization with ancestral spike-matched vaccines. It is unclear whether …

The isolation of human monoclonal antibodies is providing important insights into the specificities
that underlie broad neutralization of HIV-1 (reviewed in ref. 1 ). Here we report a broad …

… The representation of wavelet vector depends on the wavelet basis G(t) it uses. In general,
G(t) with shorter support offers better spatial locality property at the expense of the …

Motivation: The binding sites of proteins generally contain smaller regions that provide major
contributions to the binding free energy and hence are the prime targets in drug design. …