[PDF][PDF] Synthetic lethality-mediated precision oncology via the tumor transcriptome
… (G) A bar graph showing the frequency (x axis) of the drugs (y axis) predicted to be most
effective across the WINTHER cohort. (H) The correlation between the estimated coverage of top…
effective across the WINTHER cohort. (H) The correlation between the estimated coverage of top…
[HTML][HTML] Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA–Associated Pancreatic Cancer in the Clinical and Preclinical Setting
…, V Bar, A Zundelevich, I Tirosh, R Tal, G Dinstag… - Cancer discovery, 2023 - AACR
… We explored the genes that constitute the ENLIGHT PARPi network, which highlighted
the upregulation of genes involved in the G 2 –M cell-cycle checkpoint and focal adhesion …
the upregulation of genes involved in the G 2 –M cell-cycle checkpoint and focal adhesion …
PRODIGY: personalized prioritization of driver genes
G Dinstag, R Shamir - Bioinformatics, 2020 - academic.oup.com
… To produce rankings based on each measure, we calculated it on each of the networks G
p , g and summed the results over all the networks for a final ranking. Comparison with Hit’…
p , g and summed the results over all the networks for a final ranking. Comparison with Hit’…
[PDF][PDF] Clinically oriented prediction of patient response to targeted and immunotherapies from the tumor transcriptome
G Dinstag, ED Shulman, E Elis, DS Ben-Zvi, O Tirosh… - Med, 2023 - cell.com
… In combination with the interferon-g signature, ENLIGHT achieves an odds ratio larger than
4 in predicting response to immune checkpoint therapy. In the CTD scenario, ENLIGHT can …
4 in predicting response to immune checkpoint therapy. In the CTD scenario, ENLIGHT can …
[HTML][HTML] Fibrolamellar carcinoma transcriptomic-based treatment prediction: complete response after nivolumab and ipilimumab
R Berger, G Dinstag, O Tirosh, E Schiff… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Fibrolamellar carcinoma (FLC) is a rare cancer of the liver that most commonly affects children
and young adults. There is no clear standard of care for the disease, whose response to …
and young adults. There is no clear standard of care for the disease, whose response to …
[HTML][HTML] Prediction of cancer treatment response from histopathology images through imputed transcriptomics
DT Hoang, G Dinstag, LC Hermida, DS Ben-Zvi… - Research …, 2022 - ncbi.nlm.nih.gov
Advances in artificial intelligence have paved the way for leveraging hematoxylin and eosin
(H&E)-stained tumor slides for precision oncology. We present ENLIGHT-DeepPT, an …
(H&E)-stained tumor slides for precision oncology. We present ENLIGHT-DeepPT, an …
[PDF][PDF] Natural Law in Maimonidean Thought and Scholarship
JI Dienstag - Jewish Law Annual, 1987 - academia.edu
Whether or not the old rabbinic concept of Noahide Commandments, 1 which bears some
resemblance to the idea of natural law, really fits that juristic category, Maimonides' …
resemblance to the idea of natural law, really fits that juristic category, Maimonides' …
St. Thomas Aquinas in Maimonidian Scholarship
JI Dienstag - The Monist, 1974 - JSTOR
… Ludwig Stein, Das Willensfreiheit und ihr Verh ltnlss zur g ttlichen Pr scienz und Providenz
… For a list of books and articles on divine attributes in Maimonides, see Dienstag, "Moses Mai …
… For a list of books and articles on divine attributes in Maimonides, see Dienstag, "Moses Mai …
[HTML][HTML] Personalized prediction of adverse heart and kidney events using baseline and longitudinal data from SPRINT and ACCORD
Background The 2017 guidelines of the American College of Cardiology and the American
Heart Association propose substantial changes to hypertension management. The …
Heart Association propose substantial changes to hypertension management. The …
[HTML][HTML] 157 A transcriptomics-based response predictor identifies potential responders among patients with negative standard markers for response to immune …
Background Immune checkpoint blockers (ICB) are revolutionizing cancer treatment,
approved for increasingly more cancer types. The most common biomarkers currently used …
approved for increasingly more cancer types. The most common biomarkers currently used …