[PDF][PDF] Synthetic lethality-mediated precision oncology via the tumor transcriptome

JS Lee, NU Nair, G Dinstag, L Chapman, Y Chung… - Cell, 2021 - cell.com
… (G) A bar graph showing the frequency (x axis) of the drugs (y axis) predicted to be most
effective across the WINTHER cohort. (H) The correlation between the estimated coverage of top…

[HTML][HTML] Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA–Associated Pancreatic Cancer in the Clinical and Preclinical Setting

…, V Bar, A Zundelevich, I Tirosh, R Tal, G Dinstag… - Cancer discovery, 2023 - AACR
… We explored the genes that constitute the ENLIGHT PARPi network, which highlighted
the upregulation of genes involved in the G 2 –M cell-cycle checkpoint and focal adhesion …

PRODIGY: personalized prioritization of driver genes

G Dinstag, R Shamir - Bioinformatics, 2020 - academic.oup.com
… To produce rankings based on each measure, we calculated it on each of the networks G
p , g and summed the results over all the networks for a final ranking. Comparison with Hit’…

[PDF][PDF] Clinically oriented prediction of patient response to targeted and immunotherapies from the tumor transcriptome

G Dinstag, ED Shulman, E Elis, DS Ben-Zvi, O Tirosh… - Med, 2023 - cell.com
… In combination with the interferon-g signature, ENLIGHT achieves an odds ratio larger than
4 in predicting response to immune checkpoint therapy. In the CTD scenario, ENLIGHT can …

[HTML][HTML] Fibrolamellar carcinoma transcriptomic-based treatment prediction: complete response after nivolumab and ipilimumab

R Berger, G Dinstag, O Tirosh, E Schiff… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Fibrolamellar carcinoma (FLC) is a rare cancer of the liver that most commonly affects children
and young adults. There is no clear standard of care for the disease, whose response to …

[HTML][HTML] Prediction of cancer treatment response from histopathology images through imputed transcriptomics

DT Hoang, G Dinstag, LC Hermida, DS Ben-Zvi… - Research …, 2022 - ncbi.nlm.nih.gov
Advances in artificial intelligence have paved the way for leveraging hematoxylin and eosin
(H&E)-stained tumor slides for precision oncology. We present ENLIGHT-DeepPT, an …

[PDF][PDF] Natural Law in Maimonidean Thought and Scholarship

JI Dienstag - Jewish Law Annual, 1987 - academia.edu
Whether or not the old rabbinic concept of Noahide Commandments, 1 which bears some
resemblance to the idea of natural law, really fits that juristic category, Maimonides' …

St. Thomas Aquinas in Maimonidian Scholarship

JI Dienstag - The Monist, 1974 - JSTOR
… Ludwig Stein, Das Willensfreiheit und ihr Verh ltnlss zur g ttlichen Pr scienz und Providenz
… For a list of books and articles on divine attributes in Maimonides, see Dienstag, "Moses Mai …

[HTML][HTML] Personalized prediction of adverse heart and kidney events using baseline and longitudinal data from SPRINT and ACCORD

G Dinstag, D Amar, E Ingelsson, E Ashley, R Shamir - Plos one, 2019 - journals.plos.org
Background The 2017 guidelines of the American College of Cardiology and the American
Heart Association propose substantial changes to hypertension management. The …

[HTML][HTML] 157 A transcriptomics-based response predictor identifies potential responders among patients with negative standard markers for response to immune …

G Dinstag, E Elis, DS Ben-Zvi, K Aldape, E Ruppin… - 2023 - jitc.bmj.com
Background Immune checkpoint blockers (ICB) are revolutionizing cancer treatment,
approved for increasingly more cancer types. The most common biomarkers currently used …