Autophagy is a catabolic pathway used by cells to support metabolism in response to starvation
and to clear damaged proteins and organelles in response to stress. We report here that …

Macroautophagy (autophagy hereafter) degrades and recycles proteins and organelles to
support metabolism and survival in starvation. Oncogenic Ras up-regulates autophagy, and …

Autophagic elimination of defective mitochondria suppresses oxidative stress and preserves
mitochondrial function. Here, the essential autophagy gene Atg7 was deleted in a mouse …

Macroautophagy (autophagy hereafter) recycles intracellular components to sustain
mitochondrial metabolism that promotes the growth, stress tolerance, and malignancy of lung …

… preparation is described as published previously (Karsli-Uzunbas et al. 2014). For TAM
delivery to the adult mice, 200 μL of the suspended solution per 20 g of body weight was injected …

… After addition of trypsin inhibitor supplemented with DNase I (Worthington) to stop digestion,
dispersed cells were collected by centrifugation at 400 g for 10 min, counted and cultured …

… and cells were harvested by centrifugation at 300 g for 5 minutes. Then the cells were
resuspended in 1 ml of cold PBS and centrifuged again at 300 g for 5 minutes. After removal of …

Background: EGFR exon 20 insertion mutations represent a distinct subset of EGFR-mutant
lung cancer with poor prognosis generally associated with resistance to several EGFR …

Several targeted therapeutic options exist for non-small cell lung cancer (NSCLC) patients
whose tumors harbor mutations of EGFR, including L858R, exon 19 deletions, and the …

Transcriptional activation by p53 provides powerful, organism-wide tumor suppression. We
hypothesized that the local chromatin environment, including differential enhancer activities, …