10.7554/eLife.02409.001 One of the key questions in biology is how the metabolism of a
cell responds to changes in the environment. In budding yeast, starvation causes a drop in …

Venezuelan equine encephalitis virus (VEEV) is one of the most pathogenic members of the
Alphavirus genus in the Togaviridae family. Viruses in the VEEV serocomplex continuously …

Venezuelan equine encephalitis virus (VEEV) is one of the most pathogenic members of the
Alphavirus genus in the Togaviridae family. The pathogenesis of this virus depends strongly …

Mis18 is a key regulator responsible for the centromere localization of the CENP ‐A chaperone
Scm3 in Schizosaccharomyces pombe and HJURP in humans, which establishes CENP …

Background The Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) scoring system
was developed to aid the diagnosis of necrotizing fasciitis and guide management [1]. Aim …

… lipase 1523 U/L and amylase 824 U/L, haemoglobin 148 g/L, white cell count 7.0×10 9 ,
serum glucose 6.0 mmol/L, serum albumin 44 g/L, adjusted serum calcium 2.45 mmol/L, lactate …

Background The aims of this paper were to review our experience with necrotizing fasciitis
at M iddlemore H ospital and to define the trends in incidence, inpatient mortality and …

… A statistically significant reduction in mean albumin serum concentration was noted from
42.02 g/L (95% CI: 41.10–42.95) pre-operatively to 37.69 g/L (95% CI: 36.88–38.51) at the 5-…

Transcription of eukaryotic genomes is more widespread than was previously anticipated
and results in the production of many non–protein-coding RNAs (ncRNAs) whose functional …

Proteins of the conserved HP 1 family are elementary components of heterochromatin and
are generally assumed to play a central role in the creation of a rigid, densely packed …