Bone substitutes are being increasingly used in surgery as over two millions bone grafting
procedures are performed worldwide per year. Autografts still represent the gold standard for …

Background: Amyotrophic lateral sclerosis (ALS) is relatively rare, yet the economic and
social burden is substantial. Having accurate incidence and prevalence estimates would …

We have performed a systematic review to summarize current knowledge concerning factors
related to survival in ALS and to evaluate the implications of these data for clinical trials …

Background In 2010, overweight and obesity were estimated to cause 3·4 million deaths, 3·9%
of years of life lost, and 3·8% of disability-adjusted life-years (DALYs) worldwide. The rise …

Background The number of individuals living with dementia is increasing, negatively affecting
families, communities, and health-care systems around the world. A successful response …

Background Neurological disorders are now the leading source of disability globally, and
ageing is increasing the burden of neurodegenerative disorders, including Parkinson's disease…

Background Neurological disorders are increasingly recognised as major causes of death
and disability worldwide. The aim of this analysis from the Global Burden of Diseases, Injuries…

Background Comparable data on the global and country-specific burden of neurological
disorders and their trends are crucial for health-care planning and resource allocation. The …

Background Remarkable financial and political efforts have been focused on the reduction
of child mortality during the past few decades. Timely measurements of levels and trends in …

… The GGGGCC repeat expansion in the non-coding region of C9orf72 can cause ALS and
leads to the formation of stable parallel unimeric and multimeric G-quadruplex structures, …