Cancer develops through a process of somatic evolution 1 , 2 . Sequencing data from a single
biopsy represent a snapshot of this process that can reveal the timing of specific genomic …

The identification of mutations that guide therapy selection for patients with cancer is now
routine in many clinical centres. The majority of assays used for solid tumour profiling use DNA …

The genomic complexity of profound copy number aberrations has prevented effective
molecular stratification of ovarian cancers. Here, to decode this complexity, we derived copy …

Tumour heterogeneity in primary prostate cancer is a well-established phenomenon. However,
how the subclonal diversity of tumours changes during metastasis and progression to …

Chromosomal instability (CIN) results in the accumulation of large-scale losses, gains and
rearrangements of DNA 1 . The broad genomic complexity caused by CIN is a hallmark of …

Intra-tumor heterogeneity (ITH) is a mechanism of therapeutic resistance and therefore an
important clinical challenge. However, the extent, origin, and drivers of ITH across cancer …

Emerging evidence suggests that poor glycemic control mediates post-translational modifications
to the H3 histone tail. We are only beginning to understand the dynamic role of some …

Against the backdrop of a massive expansion in higher education, the number of students in
higher education (HE) experiencing mental health problems is increasing, which poses a …

… g,h, ssGSEA analysis of differentially expressed genes using hallmarks (… Copy number
signature exposures were computed using the signature definitions provided by Macintyre et al. …

… -at-CpG-C and SNP-at-CpG-G - are probes which have SNPs at the interrogated C and its
neighbouring G position, respectively; Indels - are probes which hybridize regions containing …