… g, Primary regions of spike defined for tracking progress of the opening transition. The spike
core is composed of three central helices per trimer, coloured according to chains as in a–e. …

… g c induced by coarse-graining is unknown, and, in general, conformation-dependent. g c …
, and centrifuged for 10 min at 8000×g. The supernatant was centrifuged for 20 min at 40,000×…

Using a manifold-based analysis of experimental diffraction snapshots from an X-ray free
electron laser, we determine the three-dimensional structure and conformational landscape of …

Recent approaches to the study of biological molecules employ manifold learning to single-particle
cryo-EM data sets to map the continuum of states of a molecule into a low-…

… Panels (d)–(g) show histograms of the predictions f̃ for the diffraction patterns indexed with (…
Panels (d)–(g) show histograms of the predictions f ̃ for the diffraction patterns indexed with (d…

… Ghoncheh Mashayekhi: All authors contributed to study design, extracted the manifold of
conformational motions from single particle images, produced the free-energy landscape, and …

… Monovalent cation-exchanged zeolites (Li + , K + , Cs + and Tl + ) were prepared by stirring
10 g of NaY with 100 ml of appropriate 10% nitrate aqueous solutions at 90 C for 12 h. The …

Flow mediated dilation (FMD) is a non-invasive method for endothelial function assessment
providing an index extracted from ultrasonic B-mode images. Although utilized in the …

Using experimental single-particle cryo-EM snapshots of ryanodine receptor (RyR1), a Ca 2+
-channel involved in skeletal muscle excitation/contraction coupling, we present …

Biomolecules undergo continuous conformational motions, a subset of which are functionally
relevant. Understanding, and ultimately controlling biomolecular function are predicated on …