User profiles for G. Napolitani
 | Giorgio NapolitaniUniversity of Oxford Verified email at imm.ox.ac.uk Cited by 11495 |
Duration, combination and timing: the signal integration model of dendritic cell activation
A Macagno, G Napolitani, A Lanzavecchia… - Trends in …, 2007 - cell.com
The activation of resting dendritic cells (DCs) is a crucial step in the initiation of adaptive
immunity because it links peripheral events initiated by the encounter with pathogens to the …
immunity because it links peripheral events initiated by the encounter with pathogens to the …
[HTML][HTML] Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19
…, U Rajapaksa, YL Chen, M Salio, G Napolitani… - Nature …, 2020 - nature.com
The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines
and therapeutics will depend on understanding viral immunity. We studied T cell memory …
and therapeutics will depend on understanding viral immunity. We studied T cell memory …
Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17–producing human T helper cells
EV Acosta-Rodriguez, G Napolitani… - Nature …, 2007 - nature.com
Interleukin 17 (IL-17)–producing CD4 + helper T cells (T H -17 cells) have been linked to
host defense and autoimmune diseases. In mice, the differentiation of T H -17 cells requires …
host defense and autoimmune diseases. In mice, the differentiation of T H -17 cells requires …
Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells
Interleukin 17 (IL-17)–producing T helper cells (T H -17 cells) have been characterized in
mice as a distinct subset of effector cells, but their identity and properties in humans remain …
mice as a distinct subset of effector cells, but their identity and properties in humans remain …
[HTML][HTML] AS03-and MF59-adjuvanted influenza vaccines in children
AL Wilkins, D Kazmin, G Napolitani… - Frontiers in …, 2017 - frontiersin.org
Influenza is a major cause of respiratory disease leading to hospitalization in young children.
However, seasonal trivalent influenza vaccines (TIVs) have been shown to be ineffective …
However, seasonal trivalent influenza vaccines (TIVs) have been shown to be ineffective …
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells
Toll-like receptors (TLRs) sense microbial products and initiate adaptive immune responses
by activating dendritic cells (DCs). As pathogens may contain several TLR agonists, we …
by activating dendritic cells (DCs). As pathogens may contain several TLR agonists, we …
Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells
D Jarrossay, G Napolitani, M Colonna… - European journal of …, 2001 - Wiley Online Library
Following encounter with pathogens, dendritic cells (DC) mature and migrate from peripheral
tissues to the T cell areas of secondary lymphoid organs, where they produce regulatory …
tissues to the T cell areas of secondary lymphoid organs, where they produce regulatory …
Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages
G Vitale, R Pellizzari, C Recchi, G Napolitani… - Biochemical and …, 1998 - Elsevier
Lethal factor (LF) is the major virulence factor produced byBacillus anthracis.LF is sufficient
to cause death in laboratory animals and cytolysis of peritoneal macrophages and …
to cause death in laboratory animals and cytolysis of peritoneal macrophages and …
[HTML][HTML] Predicting cross-reactivity and antigen specificity of T cell receptors
Adaptive immune recognition is mediated by specific interactions between heterodimeric T
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …
cell receptors (TCRs) and their cognate peptide-MHC (pMHC) ligands, and the methods to …
[PDF][PDF] A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
…, Y Mi, C Monaco, R Montadon, G Napolitani… - Cell, 2022 - cell.com
Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete
description of specific immune biomarkers. We present here a comprehensive multi-omic …
description of specific immune biomarkers. We present here a comprehensive multi-omic …