Increased transcription of ribosomal RNA genes (rDNA) by RNA Polymerase I is a common
feature of human cancer, but whether it is required for the malignant phenotype remains …

… Cell extracts were cleared by centrifugation at 4C for 15 min at 12,000 × g, and aliquots of
the supernatant were stored at −70C. Endogenous or myc epitope-tagged p70 S6K1 activity …

The MYC oncoprotein and transcription factor is dysregulated in a majority of human cancers
and is considered a major driver of the malignant phenotype. As such, developing drugs for …

In mammals, the mechanisms regulating the number of active copies of the ∼200 ribosomal
RNA (rRNA) genes transcribed by RNA polymerase I are unclear. We demonstrate that …

… Cultures of primary granulocytes from wild‐type (WT; Mad1+/+) and Mad1‐null (Mad1−/−)
mice were stimulated with SCF and G‐CSF. Cells were analyzed after 5 days of culture and …

CX-5461 is a first-in-class selective inhibitor of rDNA transcription. This first-in-human study
establishes the feasibility of targeting this process, demonstrating single-agent antitumor …

Acquired resistance to PARP inhibitors (PARPi) is a major challenge for the clinical management
of high grade serous ovarian cancer (HGSOC). Here, we demonstrate CX-5461, the first…

Precise regulation of ribosome biogenesis is fundamental to maintain normal cell growth
and proliferation, and accelerated ribosome biogenesis is associated with malignant …

… (G.Poortinga and SMParkhurst, unpublished). It will be interesting to determine if the function
as well as the mechanism of human CtBP is conserved in Drosophila. Since E1a is a viral …

Loss of c-MYC is required for downregulation of ribosomal RNA (rRNA) gene (rDNA) transcription
by RNA Polymerase I (Pol I) during granulocyte differentiation. Here, we demonstrate …