Trophic factor deprivation (TFD) activates c-Jun N-terminal kinases (JNKs), culminating in
coordinate AP1-dependent transactivation of the BH3-only BCL-2 proteins BIM EL and HRK, …

Programmed cell death (PCD) contributes to development, maintenance, and pathology in
various tissues, including the nervous system. Many molecular, biochemical, and genetic …

… Sympathetic neurons deprived of NGF for 24 hr in the presence of either ActD (0.1 g/ml)
or CHX (1 g/ ml) showed little, if any, upregulation of BIMEL expression (Figures 2A and 2B). …

Reactive oxygen species (ROS) such as superoxide, peroxide and hydroxyl radicals are
generated during normal cellular metabolism and are increased in acute injury and in many …

Members of the BCL-2 family of proteins either promote or repress programmed cell death.
Here we report that neonatal sympathetic neurons undergoing apoptosis after nerve growth …

… (Please note that these arguments, which are similar to those previously presented by
Putcha et al., 51 have only been strengthened by more recent findings, such as Liu et al. ) …

… Please note that the BAX, BIM, and cyt c blots have been reported previously in Putcha et al.
… Please note that the BAX, BIM, and cyt c blots have been reported previously in Putcha et al. …

Background Blood-based methods using cell-free DNA (cfDNA) are under development as
an alternative to existing screening tests. However, early-stage detection of cancer using …

Purpose: The aim of the study was to determine the actual GJB2 and GJB6 mutation
frequencies in North America after several years of generalized testing for autosomal recessive …

Ovarian malignancies occurring in the setting of hereditary nonpolyposis colorectal carcinoma
syndrome typically present in young women, often as the first or “sentinel” cancer, but the …