… Similar results were observed in young proliferating cells, where the depletion of mitochondria
resulted in decreased mTOR activity and impairment of cell proliferation (Fig EV1G and H)…

Receptor-interacting protein kinase (RIPK)-1 is involved in RIPK3-dependent and -independent
signaling pathways leading to cell death and/or inflammation. Genetic ablation of ripk1 …

Influenza A virus (IAV) is a lytic RNA virus that triggers receptor-interacting serine/threonine-protein
kinase 3 (RIPK3)-mediated pathways of apoptosis and mixed lineage kinase domain-…

Mixed lineage kinase domain-like pseudokinase (MLKL) mediates necroptosis by translocating
to the plasma membrane and inducing its rupture. The activation of MLKL occurs in a …

… deletion of BAX and BAK, but not of either alone, also inhibited Ifnb1 upregulation following
ABT-737/S63845/qVD-OPh treatment, demonstrating a requirement for MOMP (Fig 2G and H…

… Although knockdown of PGAM5 depleted protein levels (Figure S2G), it did not affect
necroptosis induced by TNF or direct activation of acRIPK3 in NIH 3T3 cells (Figure S2H), or in …

… Interestingly, we found significantly more circulating PS than PT at day 2 (Figure 1G). Next,
we measured the metastatic ratio of the injected cells, which we defined as the cancer cell …

… (G) Representative micrographs of H&E staining of the right lung cranial lobe for the indicated
K-rasLSL-G12D, p53f/f bone-marrow chimera. Scale bar, 1 mm. *p < 0.05, **p < 0.01, ***p …

Necroptosis is a cell death pathway regulated by the receptor interacting protein kinase 3 (RIPK3)
and the mixed lineage kinase domain-like (MLKL) pseudokinase. How MLKL …

… centrifuged at 600× g for 5min. The resulting supernatant fraction was centrifuged at 8000×
g for 15 min to pellet the mitochondria and washed twice for 10 min at 8000× g. To swell the …