In response to replication hindrances, DNA replication forks frequently stall and are remodelled
into a four-way junction. In such a structure the annealed nascent strand is thought to …

PARP1 regulates the repair of DNA single-strand breaks generated directly, or during base
excision repair (BER). However, the role of PARP2 in these and other repair mechanisms is …

… g–i, Colony survival after 16-h treatment with hydroxyurea was measured in HeLa (g) or
U20S (h, i) cells in which BRCA1 (g, h) or BARD1 (i) expression was knocked down by siRNA …

… GFP (G) and the Zα domain are indicated. (f and g) HeLa cells were transiently transfected
… (f and g) HeLa cells were transiently transfected with an expression vector for GFP-E3L (f) or …

A synthetic lethal relationship exists between disruption of polymerase theta (Polθ), and loss
of either 53BP1 or homologous recombination (HR) proteins, including BRCA1; however, …

SUMOylation (small ubiquitin-like modifier) in the DNA double-strand break (DSB) response
regulates recruitment, activity, and clearance of repair factors. However, our understanding …

While the toxicity of PARP inhibitors to cells with defects in homologous recombination (HR)
is well established, other synthetic lethal interactions with PARP1/PARP2 disruption are …

The emergence of antiretroviral therapies extends the life span of people diagnosed with
HIV and shifts health priorities toward chronic disease management. People living with HIV (…

A Canadian biennial youth survey facilitated repeating investigation of susceptibility to smoke
and household socialization. We operationalized susceptibility to smoke by 3 levels on the …

… Ronson quit school before his lSth birthday to work with his father In the family's furniture …
which Ronson calls the greatest crisis in his "ET. " he suffered a major financial crash that …