Risk for late-onset Alzheimer’s disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association …

Previous genome-wide association studies (GWASs) of stroke — the second leading cause
of death worldwide — were conducted predominantly in populations of European ancestry 1 …

Human brain structure changes throughout the lifespan. Altered brain growth or rates of
decline are implicated in a vast range of psychiatric, developmental and neurodegenerative …

Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens, …

The gap between predicted brain age using magnetic resonance imaging (MRI) and chronological
age may serve as a biomarker for early-stage neurodegeneration. However, owing to …

Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance
imaging marker of cerebral small vessel disease, a leading cause of stroke and dementia. …

The human microbiome has emerged as a central research topic in human biology and
biomedicine. Current microbiome studies generate high-throughput omics data across different …

Background and Purpose: Periventricular white matter hyperintensities (WMH; PVWMH) and
deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences …

The volumes of subcortical brain structures are highly heritable, but genetic underpinnings
of their shape remain relatively obscure. Here we determine the relative contribution of …

Cortical thickness, surface area and volumes vary with age and cognitive function, and in
neurological and psychiatric diseases. Here we report heritability, genetic correlations and …