Author to whom correspondence should be addressed. Electronic mail: rgg@ mit. edu.
Phone:+ 1 617-253-5597. FAX:+ 1 617-253-5404. URL: http://web. mit. edu/fbml/cmr/griffin …

The cross-β amyloid form of peptides and proteins represents an archetypal and widely
accessible structure consisting of ordered arrays of β-sheet filaments. These complex …

Exciting new technological developments have pushed the boundaries of structural biology,
and have enabled studies of biological macromolecules and assemblies that would have …

We describe magic-angle spinning NMR experiments designed to elucidate the interstrand
architecture of amyloid fibrils. Three methods are introduced for this purpose, two being …

Microwave driven dynamic nuclear polarization (DNP) is a process in which the large
polarization present in an electron spin reservoir is transferred to nuclei, thereby enhancing NMR …

All amyloid fibrils contain a cross-β fold. How this structure differs in fibrils formed from proteins
associated with different diseases remains unclear. Here, we combine cryo-EM and MAS-…

We report the Z-selective and syndioselective polymerization of 2,3-bis(trifluoromethyl)bicyclo[2.2.1]hepta-2,5-diene
(NBDF6) and 3-methyl-3-phenylcyclopropene (MPCP) by …

Dynamic nuclear polarization (DNP) utilizes the inherently larger polarization of electrons to
enhance the sensitivity of conventional solid-state NMR experiments at low temperature. …

Ubiquitylation of histone H2B, associated with gene activation, leads to chromatin decompaction
through an unknown mechanism. We used a hydrogen–deuterium exchange strategy …

The eukaryotic genome is packaged into chromatin, a polymer of DNA and histone proteins
that regulates gene expression and the spatial organization of nuclear content. The …