Imaging is crucial in the assessment of children with a primary hepatic malignancy. Since its
inception in 1992, the PRETEXT (PRE-Treatment EXTent of tumor) system has become the …

International collaborative efforts in hepatoblastoma have led to increased refinements in
the use of the PRETEXT and post-treatment extent to define prognosis and surgical …

Large-scale reference data sets of human genetic variation are critical for the medical and
functional interpretation of DNA sequence changes. Here we describe the aggregation and …

… for SNVs in exomes (c; x axis shared with e and g) and genomes (d; x axis shared with f and
h). … g, h, The total number of variants observed in each functional class for exomes (g) and …

Its main objective is to examine the application and relevance of Bayes' theorem to problems
that arise in scientific investigation in which inferences must be made regarding parameter …

This article discusses the effect of interventions on a given response variable in the presence
of dependent noise structure. Difference equation models are employed to represent the …

We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …

Rare coding variation has historically provided the most direct connections between gene
function and disease pathogenesis. By meta-analysing the whole exomes of 24,248 …

Genetic variants that inactivate protein-coding genes are a powerful source of information
about the phenotypic consequences of gene disruption: genes critical for an organism’s …

Structural variants (SVs) rearrange large segments of DNA 1 and can have profound
consequences in evolution and human disease 2 , 3 . As national biobanks, disease-association …