Altered interplay between endoplasmic reticulum and mitochondria in Charcot–Marie–Tooth type 2A neuropathy

N Bernard-Marissal, G van Hameren… - Proceedings of the …, 2019 - National Acad Sciences
Mutations in the MFN2 gene encoding Mitofusin 2 lead to the development of Charcot–Marie–Tooth
type 2A (CMT2A), a dominant axonal form of peripheral neuropathy. Mitofusin 2 is …

[HTML][HTML] In vivo real-time dynamics of ATP and ROS production in axonal mitochondria show decoupling in mouse models of peripheral neuropathies

G van Hameren, G Campbell, M Deck… - Acta neuropathologica …, 2019 - Springer
Mitochondria are critical for the function and maintenance of myelinated axons notably through
Adenosine triphosphate (ATP) production. A direct by-product of this ATP production is …

Memantine inhibits cortical spreading depolarization and improves neurovascular function following repetitive traumatic brain injury

…, JH Muradov, R Greene, G Van Hameren… - Science …, 2023 - science.org
Cortical spreading depolarization (CSD) is a promising target for neuroprotective therapy in
traumatic brain injury (TBI). We explored the effect of NMDA receptor antagonism on …

[HTML][HTML] Mitochondrial dysfunction underlies impaired neurovascular coupling following traumatic brain injury

G Van Hameren, J Muradov, A Minarik… - Neurobiology of …, 2023 - Elsevier
Traumatic brain injury (TBI) involves an acute injury (primary damage), which may evolve in
the hours to days after impact (secondary damage). Seizures and cortical spreading …

Concussion susceptibility is mediated by spreading depolarization-induced neurovascular dysfunction

…, CP Doherty, M Campbell, DB Clarke, G van Hameren… - Brain, 2022 - academic.oup.com
The mechanisms underlying the complications of mild traumatic brain injury, including post-concussion
syndrome, post-impact catastrophic death, and delayed neurodegeneration …

[HTML][HTML] Brainstem and cortical spreading depolarization in a closed head injury rat model

…, JP Dreier, A Friedman, G van Hameren - International Journal of …, 2021 - mdpi.com
Traumatic brain injury (TBI) is the leading cause of death in young individuals, and is a
major health concern that often leads to long-lasting complications. However, the …

[HTML][HTML] Traumatic and diabetic Schwann cell demyelination is triggered by a transient mitochondrial calcium release through voltage dependent anion channel 1

…, B Gautier, J Berthelot, S Gonzalez, G Van Hameren - Biomedicines, 2022 - mdpi.com
A large number of peripheral neuropathies, among which are traumatic and diabetic
peripheral neuropathies, result from the degeneration of the myelin sheath, a process called …

[HTML][HTML] Physiology of PNS axons relies on glycolytic metabolism in myelinating Schwann cells

M Deck, G Van Hameren, G Campbell… - Plos one, 2022 - journals.plos.org
While lactate shuttle theory states that glial cells metabolize glucose into lactate to shuttle it
to neurons, how glial cells support axonal metabolism and function remains unclear. Lactate …

[HTML][HTML] Automatic trait estimation in floriculture using computer vision and deep learning

…, H Zwinkels, M Rijsbergen, G van Hameren… - Smart Agricultural …, 2024 - Elsevier
Registration of new varieties of ornamental flowers is an important process in protecting
plant breeders' intellectual property as well as consumer rights. One of the first steps in the …

Determining flower colors from images using artificial intelligence

…, J Paulo, G Polder, M Rijsbergen, G van Hameren… - Euphytica, 2024 - Springer
Flower color is one of the most important traits in horticulture, and is one of the
characteristics recorded to describe new varieties. In this paper, we examine four large real-world …