“Food addiction” has become a focus of interest for researchers attempting to explain certain
processes and/or behaviors that may contribute to the development of obesity. Although the …

The anorexigenic hormone leptin plays an important role in the control of food intake and
feeding-related behavior, for an important part through its action in the hypothalamus. The …

Feeding behaviour is crucial for the survival of an organism and is regulated by different
brain circuits. Among these circuits the mesolimbic dopamine (DA) system is implicated in the …

We here describe a technique to transiently activate specific neural pathways in vivo. It
comprises the combined use of a CRE-recombinase expressing canine adenovirus-2 (CAV-2) …

Results: Animals showed an increase in performance following mild food restriction (P= 0.002).
Importantly, food-cue induced DA firing increased when animals were food restricted (P= …

Hyperactivity is a core symptom in various psychiatric disorders, including attention-deficit/hyperactivity
disorder, schizophrenia, bipolar disorders, and anorexia nervosa. Although …

The orbitofrontal cortex (OFC) has been implicated in decision-making under uncertainty, but
it is unknown how information about the probability or uncertainty of future reward is coded …

Following the successful application of deep brain stimulation (DBS) in the treatment of
Parkinson's disease and promising results in clinical trials for obsessive compulsive disorder and …

Daily variations in plasma glucose concentrations are controlled by the biological clock,
located in the suprachiasmatic nucleus. Our previous studies indicated an important role for the …

Background: Dopamine (DA) signalling in the brain is necessary for feeding behaviour, and
alterations in the DA system have been linked to obesity. However, the precise role of DA in …