User profiles for G.N. Wheeler
Grant N WheelerReader in Cell and Developmental Biology, University of East Anglia, Norwich, UK Verified email at uea.ac.uk Cited by 3633 |
[HTML][HTML] The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family
The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) enzymes
are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse …
are secreted, multi-domain matrix-associated zinc metalloendopeptidases that have diverse …
Simple vertebrate models for chemical genetics and drug discovery screens: Lessons from zebrafish and Xenopus
GN Wheeler, AW Brändli - Developmental Dynamics, 2009 - Wiley Online Library
Chemical genetics uses small molecules to modulate protein function and, in principle, has
the potential to perturb any biochemical event in a complex cellular context. The application …
the potential to perturb any biochemical event in a complex cellular context. The application …
DHODH modulates transcriptional elongation in the neural crest and melanoma
…, S Granter, RA Young, S Morrison, GN Wheeler… - Nature, 2011 - nature.com
Melanoma is a tumour of transformed melanocytes, which are originally derived from the
embryonic neural crest. It is unknown to what extent the programs that regulate neural crest …
embryonic neural crest. It is unknown to what extent the programs that regulate neural crest …
Binding of integrin α6β4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding
…, RQJ Schaapveld, PE Purkis, GN Wheeler… - The Journal of cell …, 1999 - rupress.org
Hemidesmosomes are stable adhesion complexes in basal epithelial cells that provide a
link between the intermediate filament network and the extracellular matrix. We have …
link between the intermediate filament network and the extracellular matrix. We have …
[HTML][HTML] Wnt/β-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration
…, P Coronel-Córdoba, MS Magri, GN Wheeler… - Nature …, 2023 - nature.com
For successful regeneration, the identity of the missing tissue must be specified according to
the pre-existing tissue. Planarians are ideal for the study of the mechanisms underlying this …
the pre-existing tissue. Planarians are ideal for the study of the mechanisms underlying this …
[HTML][HTML] Frizzled7 mediates canonical Wnt signaling in neural crest induction
The neural crest is a multipotent cell population that migrates from the dorsal edge of the
neural tube to various parts of the embryo where it differentiates into a remarkable variety of …
neural tube to various parts of the embryo where it differentiates into a remarkable variety of …
myomiR-dependent switching of BAF60 variant incorporation into Brg1 chromatin remodeling complexes during embryo myogenesis
…, A Fahad Alrefaei, N Kennerley, GN Wheeler… - …, 2014 - journals.biologists.com
Myogenesis involves the stable commitment of progenitor cells followed by the execution of
myogenic differentiation, processes that are coordinated by myogenic regulatory factors, …
myogenic differentiation, processes that are coordinated by myogenic regulatory factors, …
Solid lipid nanoparticles for the delivery of anti-microbial oligonucleotides
…, L Sitia, A Ruyra, CJ Morris, GN Wheeler… - European journal of …, 2019 - Elsevier
Novel alternatives to antibiotics are urgently needed for the successful treatment of antimicrobial
resistant (AMR) infections. Experimental antibacterial oligonucleotide therapeutics, …
resistant (AMR) infections. Experimental antibacterial oligonucleotide therapeutics, …
Xenopus: An ideal system for chemical genetics
GN Wheeler, KJ Liu - Genesis, 2012 - Wiley Online Library
… There are many sources for such libraries as discussed in Wheeler and Brandli,2009. Of
course, the choice of the library depends on the researchers' initial goals and will greatly affect …
course, the choice of the library depends on the researchers' initial goals and will greatly affect …
Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules.
GN Wheeler, AE Parker, CL Thomas… - Proceedings of the …, 1991 - National Acad Sciences
Among the variety of specialized intercellular junctions, those of the adherens type have the
most obvious association with cytoskeletal elements. This may be with the actin …
most obvious association with cytoskeletal elements. This may be with the actin …