Cerebral organoids, three-dimensional cultures that model organogenesis, provide a new
platform to investigate human brain development. High cost, variability, and tissue …

Human induced pluripotent stem cells (hiPSCs) are a powerful model of neural differentiation
and maturation. We present a hiPSC transcriptomics resource on corticogenesis from 5 …

Transcription Factor 4 (TCF4) is a clinically pleiotropic gene associated with schizophrenia
and Pitt-Hopkins syndrome (PTHS). To gain insight about the neurobiology of TCF4, we …

Disruption of the laminar and columnar organization of the brain is implicated in several
psychiatric disorders. Here, we show in utero gain-of-function of the psychiatric risk gene …

Transcription factor 4 (TCF4) is a basic helix-loop-helix transcription factor that is implicated
in a variety of psychiatric disorders including autism spectrum disorder (ASD), major …

Background Context fear memory dysregulation is a hallmark symptom of several neuropsychiatric
disorders, including generalized anxiety disorder and posttraumatic stress disorder. …

Categorical sensory representations are critical for many behaviors, including speech
perception. In the auditory system, categorical information is thought to arise hierarchically, …

In everyday hearing, listeners encounter complex auditory scenes containing overlapping
sounds that must be grouped into meaningful sources, or streamed, to be perceived accurately…

Sandhoff disease, one of the GM2 gangliosidoses, is a lysosomal storage disorder characterized
by the absence of β-hexosaminidase A and B activity and the concomitant lysosomal …