Coronaviruses are enveloped positive-stranded RNA viruses that replicate in the cytoplasm.
To deliver their nucleocapsid into the host cell, they rely on the fusion of their envelope with …

The coronavirus spike protein (S) plays a key role in the early steps of viral infection, with the
S1 domain responsible for receptor binding and the S2 domain mediating membrane fusion…

… , during virus entry into target cells (Millet and Whittaker, 2014). Similarly to the situation with
… We are grateful to all members of the Whittaker laboratory for helpful discussions. This work …

β-Coronaviruses are a family of positive-strand enveloped RNA viruses that includes the
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Much is known regarding …

The coronavirus disease 2019 (COVID-19) pandemic has focused attention on the need to
develop effective therapies against the causative agent, SARS-CoV-2, and also against other …

The 2019 novel coronavirus (2019-nCoV/SARS-CoV-2) originally arose as part of a major
outbreak of respiratory disease centered on Hubei province, China. It is now a global …

Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly identified betacoronavirus
causing high morbidity and mortality in humans. The coronavirus spike (S) protein is …

… In these cells, influenza virus entry was arrested at the level of the late endosome (SB
Sieczkarski, HA Brown and GR Whittaker, unpublished data), without any apparent defect in …

Influenza virus has been described to enter host cells via clathrin-mediated endocytosis.
However, it has also been suggested that other endocytic routes may provide additional entry …

… We thank Ruth Collins and all member of the Whittaker and Daniel labs at Cornell University
for comments and discussion. Work in the author’s laboratory is supported by the National …