Natural genetic variation can cause significant differences in gene expression, but little is
known about the polymorphisms that affect gene regulation. We analyzed regulatory variation …

To begin to understand the genetic architecture of natural variation in gene expression, we
carried out genetic linkage analysis of genomewide expression patterns in a cross between a …

The gene for spinocerebellar ataxia 7 (SCA7) has been mapped to chromosome 3p12–13.
By positional cloning, we have identified a new gene of unknown function containing a CAG …

The genetic control of common traits is rarely deterministic, with many genes contributing
only to the chance of developing a given phenotype. This incomplete penetrance is poorly …

Functional genomics relies on two essential parameters: the sensitivity of phenotypic
measures and the power to detect genomic perturbations that cause phenotypic variations. In …

Among the eight progressive neurodegenerative diseases caused by polyglutamine
expansions, spinocerebellar ataxia type 7 (SCA7) is the only one to display degeneration in both …

Natural Saccharomyces cerevisiae yeast strains exhibit very large genotypic and phenotypic
diversity. However, the link between phenotype variation and genetic determinism is still …

Two forms of the neurodegenerative disorder spinocerebellar ataxia are known to be
caused by the expansion of a CAG (polyglutamine) trinucleotide repeat. By screening cDNA …

Accumulation of expanded polyglutamine proteins and selective pattern of neuronal loss are
hallmarks of at least eight neurodegenerative disorders, including spinocerebellar ataxia …

Huntington's disease (HD) and spinocerebellar ataxia type 7 (SCA7) belong to a group of
progressive neurodegenerative diseases caused by polyglutamine (polyQ) expansions. SCA7 …