There is currently little information available about how individual cell types contribute to
Alzheimer’s disease. Here we applied single-nucleus RNA sequencing to entorhinal cortex …

The role of microglia cells in Alzheimer’s disease (AD) is well recognized, however their
molecular and functional diversity remain unclear. Here, we isolated amyloid plaque-containing (…

Microglia, the main immune cells of the central nervous system, are increasingly implicated
in Alzheimer’s disease (AD). Manifold transcriptomic studies in the brain have not only …

Background Renal fibrosis is a common pathological endpoint in CKD that is challenging to
reverse, and myofibroblasts are responsible for the accumulation of a fibrillar collagen-rich …

Alzheimer’s disease (AD) is a heterogeneous disease that is largely dependent on the
complex cellular microenvironment in the brain. This complexity impedes our understanding of …

Non-ischemic cardiomyopathy (NICM) can cause left ventricular dysfunction through interstitial
fibrosis, which corresponds to the failure of cardiac tissue remodeling. Recent evidence …

The important role of microglia, the brain’s resident immune cells, in Alzheimer’s disease (AD)
is now well recognized, however their molecular and functional diversity and underlying …

A major pathway in hypertension pathogenesis involves direct activation of ANG II type 1 (AT
1 ) receptors in the kidney, stimulating Na + reabsorption. AT 1 receptors in tubular …

Decoding of directional information in the motor cortex traditionally utilizes only firing rate
information. However, information from other features could be extracted and combined with …

Background: Tremor is related to abnormal structure of a cerebello-thalamo-cortical brain
network. Previous essential tremor RNA-sequencing studies focused on the cerebellar cortex, …