Translation accuracy is one of the most critical factors for protein synthesis. It is regulated by
the ribosome and its dynamic behavior, along with translation factors that direct ribosome …

Gene translation depends on accurate decoding of mRNA, the structural mechanism of
which remains poorly understood. Ribosomes decode mRNA codons by selecting cognate …

During translation, a conserved GTPase elongation factor—EF-G in bacteria or eEF2 in
eukaryotes—translocates tRNA and mRNA through the ribosome. EF-G has been proposed to …

In animals and plants, Dicer enzymes collaborate with double-stranded RNA-binding domain
(dsRBD) proteins to convert precursor-microRNAs (pre-miRNAs) into miRNA duplexes. We …

Ribosomes accurately decode mRNA by proofreading each aminoacyl-tRNA that is
delivered by the elongation factor EF-Tu 1 . To understand the molecular mechanism of this …

10.7554/eLife.28560.001 In bacteria, mRNA transcription and translation are coupled to
coordinate optimal gene expression and maintain genome stability. Coupling is thought to …

Toxic dipeptide-repeat (DPR) proteins are produced from expanded G 4 C 2 repeats in the
C9ORF72 gene, the most common genetic cause of amyotrophic lateral sclerosis (ALS) and …

Sliding clamps are ring-shaped protein complexes that are integral to the DNA replication
machinery of all life. Sliding clamps are opened and installed onto DNA by clamp loader AAA+ …

The capsids of double-stranded DNA viruses protect the viral genome from the harsh
extracellular environment, while maintaining stability against the high internal pressure of …

10.7554/eLife.23687.001 ArfA rescues ribosomes stalled on truncated mRNAs by recruiting
release factor RF2, which normally binds stop codons to catalyze peptide release. We report …